Journal of the neurological sciences · 2015
Dopaminergic denervation is not necessary to induce gait disorders in atypical parkinsonian syndrome.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Allali Gilles, Garibotto Valentina, Mainta Ismini C, Armand Stephane, Camicioli Richard, Ratib Osman, Zaidi Habib, Herrmann Francois R, Assal Frederic
Аннотация
BACKGROUND: Gait impairment is common in parkinsonian syndromes but not specific to striatonigral dysfunction. The relationship between the dopaminergic system and gait parameters is poorly understood. This cross-sectional study aimed to determine if gait measures are related to the striatal dopamine transporters distribution using [(123)I]FP-CIT SPECT in patients with parkinsonian syndromes.
MATERIALS AND METHODS: Twenty-four patients with gait impairment and parkinsonian syndromes without Parkinson's disease (mean age: 73.6±8.2years) were included in this study. Gait analysis during single- and dual-task condition (walking and backwards counting) and [(123)I]FP-CIT SPECT were performed within 3months of each other. Patients were visually categorized as having normal (n=14) or abnormal (n=10) [(123)I]FP-CIT SPECT. In addition, a volume-of-interest-based analysis of uptake ratios (caudate and putamen) relative to the occipital cortex and a voxelwise analysis using SPM8 were also performed.
RESULTS: Patients with parkinsonian syndromes and abnormal [(123)I]FP-CIT SPECT did not significantly differ in terms of spatiotemporal gait parameters from those with normal [(123)I]FP-CIT SPECT. Moreover, after correction for multiple comparisons, we did not observe any association between regional uptake ratio and spatiotemporal gait parameters for single and dual tasking. Finally, none of these parameters showed a significant association with voxelwise [(123)I]FP-CIT uptake.
CONCLUSIONS: Dopaminergic denervation, as measured by [(123)I]FP-CIT SPECT, is not necessary to induce alterations of spatiotemporal gait parameters during single and dual task in patients presenting with atypical parkinsonian syndromes.
MATERIALS AND METHODS: Twenty-four patients with gait impairment and parkinsonian syndromes without Parkinson's disease (mean age: 73.6±8.2years) were included in this study. Gait analysis during single- and dual-task condition (walking and backwards counting) and [(123)I]FP-CIT SPECT were performed within 3months of each other. Patients were visually categorized as having normal (n=14) or abnormal (n=10) [(123)I]FP-CIT SPECT. In addition, a volume-of-interest-based analysis of uptake ratios (caudate and putamen) relative to the occipital cortex and a voxelwise analysis using SPM8 were also performed.
RESULTS: Patients with parkinsonian syndromes and abnormal [(123)I]FP-CIT SPECT did not significantly differ in terms of spatiotemporal gait parameters from those with normal [(123)I]FP-CIT SPECT. Moreover, after correction for multiple comparisons, we did not observe any association between regional uptake ratio and spatiotemporal gait parameters for single and dual tasking. Finally, none of these parameters showed a significant association with voxelwise [(123)I]FP-CIT uptake.
CONCLUSIONS: Dopaminergic denervation, as measured by [(123)I]FP-CIT SPECT, is not necessary to induce alterations of spatiotemporal gait parameters during single and dual task in patients presenting with atypical parkinsonian syndromes.