Epilepsy & behavior : E&B · 2022
Abnormalities of hemispheric specialization in drug-naïve and drug-receiving self-limited epilepsy with centrotemporal spikes.
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Yin Yu, Wang Fuqin, Yang Yang, Tian Maoqiang, Gao Lei, Liu Heng
Аннотация
PURPOSE: Self-limited epilepsy with centrotemporal spikes (SLECTS) is a pediatric benign epilepsy but often accompanied by subsequent (in adulthood) functional changes such as language, which are thought to have distinct areas of hemispheric lateralization and functional differentiation. This study aimed to explore hemispheric specialization measured by resting-state functional magnetic resonance imaging (rs-fMRI) functional connectivity in drug-naïve and drug-receiving SLECTS.
METHODS: Hemispheric specialization was quantified in three groups of children, including 21 drug-naïve patients (DNP) with SLECTS, 34 drug-receiving patients (DRP) with SLECTS and 36 demographically matched typical development (TD).
RESULTS: Compared with the TD group, both the DNP and DRP groups exhibited significantly higher specialization in the left superior temporal gyrus, right parahippocampus, left putamen, and right caudate. The DNP group exhibited significantly higher hemispheric specialization in the right precentral gyrus and right inferior temporal gyrus, while the DRP group demonstrated significantly higher hemispheric specialization in the left postcentral gyrus and right hippocampus than the TD group. Furthermore, bilateral cerebellum_6 showed opposing hemispheric specialization trends in the two patient groups. Further meta-analytical mapping demonstrated that hemispheric specialization-related differential brain regions are primarily involved in language processing.
CONCLUSION: Our findings showed that children with SLECTS had altered hemispheric specialization, mainly in language processing regions, suggesting both abnormal intrahemispheric segregation and interhemispheric integration in these children.
METHODS: Hemispheric specialization was quantified in three groups of children, including 21 drug-naïve patients (DNP) with SLECTS, 34 drug-receiving patients (DRP) with SLECTS and 36 demographically matched typical development (TD).
RESULTS: Compared with the TD group, both the DNP and DRP groups exhibited significantly higher specialization in the left superior temporal gyrus, right parahippocampus, left putamen, and right caudate. The DNP group exhibited significantly higher hemispheric specialization in the right precentral gyrus and right inferior temporal gyrus, while the DRP group demonstrated significantly higher hemispheric specialization in the left postcentral gyrus and right hippocampus than the TD group. Furthermore, bilateral cerebellum_6 showed opposing hemispheric specialization trends in the two patient groups. Further meta-analytical mapping demonstrated that hemispheric specialization-related differential brain regions are primarily involved in language processing.
CONCLUSION: Our findings showed that children with SLECTS had altered hemispheric specialization, mainly in language processing regions, suggesting both abnormal intrahemispheric segregation and interhemispheric integration in these children.