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Войти в исследования Oral surgery, oral medicine, oral pathology and oral radiology · 2013
WWOX expression in giant cell lesions of the jaws.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Amaral Fabrício Rezende, Diniz Marina Gonçalves, Bernardes Vanessa Fátima, Souza Paulo Eduardo Alencar, Gomez Ricardo Santiago, Gomes Carolina Cavaliéri
Аннотация
OBJECTIVE: To investigate WWOX messenger RNA (mRNA) transcriptional levels in giant cell lesions (GCLs) of the jaws and associate its expression with clinical parameters.
STUDY DESIGN: In this pilot study, quantitative reverse-transcription polymerase chain reaction was performed to analyze WWOX expression in 6 central giant cell lesions (CGCLs) (including 2 aggressive), 5 peripheral giant cell lesions (PGCLs) and 1 cherubism sample. Immunohistochemistry was performed to confirm the localization of the Wwox protein.
RESULTS: CGCL and PGCL showed an overall increased expression of WWOX, as did the cherubism case, but no differences were observed among the groups. Wwox was localized almost entirely to the cytoplasm of multinucleated giant cells, as well as in a few mononuclear cells. CGCL and PGCL showed higher expression of the WWOX mRNA than peripheral blood mononuclear cells. The 2 aggressive CGCL samples exhibited decreased WWOX expression.
CONCLUSIONS: These results showed increased expression of WWOX mainly in non-aggressive GCLs of the jaws.
STUDY DESIGN: In this pilot study, quantitative reverse-transcription polymerase chain reaction was performed to analyze WWOX expression in 6 central giant cell lesions (CGCLs) (including 2 aggressive), 5 peripheral giant cell lesions (PGCLs) and 1 cherubism sample. Immunohistochemistry was performed to confirm the localization of the Wwox protein.
RESULTS: CGCL and PGCL showed an overall increased expression of WWOX, as did the cherubism case, but no differences were observed among the groups. Wwox was localized almost entirely to the cytoplasm of multinucleated giant cells, as well as in a few mononuclear cells. CGCL and PGCL showed higher expression of the WWOX mRNA than peripheral blood mononuclear cells. The 2 aggressive CGCL samples exhibited decreased WWOX expression.
CONCLUSIONS: These results showed increased expression of WWOX mainly in non-aggressive GCLs of the jaws.
Предметные рубрики MeSH
AdultApoptosisCherubismChildCytoplasmFemaleGiant CellsGingival DiseasesGranuloma, Giant CellHumansImmunohistochemistryJaw DiseasesLeukocytes, MononuclearMaleMandibular DiseasesMaxillary DiseasesMiddle AgedOxidoreductasesPilot ProjectsReverse Transcriptase Polymerase Chain ReactionTumor Suppressor ProteinsWW Domain-Containing OxidoreductaseYoung Adult