Медицинская библиотека · Expert opinion on biological therapy · 2013

Bone formation in calvarial defects by injectable nanoparticular scaffold loaded with stem cells.

Biazar Esmaeil, Heidari Keshel Saeed, Rezaei Tavirani Mostafa, Jahandideh Rahim

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Аннотация

OBJECTIVE

Calcium phosphates are one of biomaterials that are used for bone regeneration. In this study, calcium phosphate nanoparticles such as hydroxyapatite (HA)/fluorapatite (FA),with chitosan gel filled with unrestricted somatic stem cells (USSCs) were used for healing calvarial bone in rat model.

METHODS

The healing effects of these injectable scaffolds, with and without stem cells, in bone regeneration were investigated by computed tomography (CT) analysis and pathology assays after 28 days of grafting.

RESULTS

The results of CT analysis showed that bone regeneration on the scaffolds, and the amounts of regenerated new bone for USSC scaffold were significantly greater than the scaffold without cell and untreated controls.

CONCLUSION

Therefore, the combination of scaffold especially with USSC could be considered as a useful method for bone regeneration.

Для цитирования: Biazar Esmaeil, Heidari Keshel Saeed, Rezaei Tavirani Mostafa, Jahandideh Rahim. Bone formation in calvarial defects by injectable nanoparticular scaffold loaded with stem cells.. Expert opinion on biological therapy. 2013. DOI: 10.1517/14712598.2013.840284.

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