Медицинская библиотека · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2009

Effectiveness of topically applied halofuginone in management of subglottic stenosis in rats.

Ertuğrul Eylem Ertug, Cekin I Engin, Cincik Hakan, Doğru Salim, Güngör Atila

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Аннотация

OBJECTIVE

The aim of the study is to ascertain the antifibrotic effect of topically applied halofuginone after acute subglottic injury.

MATERIALS AND

METHODS

After standardized trauma to subglottic area, rats were divided into two groups: the study group that received treatment and the control group that did not. The subjects were treated with topical application of cottonoid soaked in 30 mg/dL halofuginone solution for 5 minutes after subglottic trauma. The larynx specimens were examined histopathologically by light microscopy to assess fibrosis, epithelialization, inflammation, and necrosis.

RESULTS

The fibrosis indexes of the treated group were significantly less than those of the control group (P < 0.05).

CONCLUSIONS

Topically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.

Для цитирования: Ertuğrul Eylem Ertug, Cekin I Engin, Cincik Hakan, Doğru Salim, Güngör Atila. Effectiveness of topically applied halofuginone in management of subglottic stenosis in rats.. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2009. DOI: 10.1016/j.otohns.2008.12.050.

Предметные рубрики MeSH

Administration, Topical Animals Fibrosis Laryngostenosis Piperidines Protein Synthesis Inhibitors Quinazolinones Rats Rats, Sprague-Dawley Statistics, Nonparametric

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