Neurology India · 2019
Differential DNA Methylation Patterns in Patients with Epilepsy due to Malformations of Cortical Development: A Pilot Study.
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Sen Kuntal, Gadkari Rupali, Agarwal Rajkumar, Sundaram Senthil
Аннотация
OBJECTIVE: To study the DNA methylation profiles in brain tissue of patients with refractory epilepsy due to malformations of cortical development (MCDs).
MATERIALS AND METHODS: Clinical, neuroimaging, and pathology characteristics were defined for 13 patients who underwent resective surgery for epilepsy. Methylation analysis was performed using Illumina® 450k Methylation Microarray. Data analysis was completed, and pathway identification was done using the R/Bioconductor package.
RESULTS: Genes associated with Ephrin-Reelin pathway, potassium channels, and glutathione metabolism were differentially methylated in the MCD group when compared with patients who had no evidence of MCD.
CONCLUSIONS: Our preliminary data reveal that epigenetic pathways may have a role in the pathobiogenesis of MCDs.
MATERIALS AND METHODS: Clinical, neuroimaging, and pathology characteristics were defined for 13 patients who underwent resective surgery for epilepsy. Methylation analysis was performed using Illumina® 450k Methylation Microarray. Data analysis was completed, and pathway identification was done using the R/Bioconductor package.
RESULTS: Genes associated with Ephrin-Reelin pathway, potassium channels, and glutathione metabolism were differentially methylated in the MCD group when compared with patients who had no evidence of MCD.
CONCLUSIONS: Our preliminary data reveal that epigenetic pathways may have a role in the pathobiogenesis of MCDs.