The Laryngoscope · 2007
Effects of halofuginone on fibrosis formation secondary to experimentally induced subglottic trauma.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Ertuğrul E Eylem, Cincik Hakan, Dogru Salim, Cekin Engin, Berber Ufuk, Gungor Atila, Poyrazoğlu I Ethem
Аннотация
OBJECTIVE: The aim of the study was to assess the antifibrotic effect of systemically applied halofuginone after subglottic injury.
MATERIALS AND METHODS: After standardized trauma to subglottic area, rats were divided into two groups: a study group that received treatment and a control group that did not. The rats were treated with 0.1 mg/kg/day intraperitoneal halofuginone injection for 30 days. The larynx specimens were examined histopathologically under light microscope for epithelization, inflammation, necrosis, and fibrosis.
RESULTS: The fibrosis indexes of the treated group were significantly less than those of the control group (P < .01).
CONCLUSIONS: Systemically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.
MATERIALS AND METHODS: After standardized trauma to subglottic area, rats were divided into two groups: a study group that received treatment and a control group that did not. The rats were treated with 0.1 mg/kg/day intraperitoneal halofuginone injection for 30 days. The larynx specimens were examined histopathologically under light microscope for epithelization, inflammation, necrosis, and fibrosis.
RESULTS: The fibrosis indexes of the treated group were significantly less than those of the control group (P < .01).
CONCLUSIONS: Systemically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.