Медицинская библиотека · The Laryngoscope · 2007

Effects of halofuginone on fibrosis formation secondary to experimentally induced subglottic trauma.

Ertuğrul E Eylem, Cincik Hakan, Dogru Salim, Cekin Engin, Berber Ufuk, Gungor Atila, Poyrazoğlu I Ethem

Сравнительное исследованиеСтатьяПеревод в очереди

Аннотация

OBJECTIVE

The aim of the study was to assess the antifibrotic effect of systemically applied halofuginone after subglottic injury.

MATERIALS AND

METHODS

After standardized trauma to subglottic area, rats were divided into two groups: a study group that received treatment and a control group that did not. The rats were treated with 0.1 mg/kg/day intraperitoneal halofuginone injection for 30 days. The larynx specimens were examined histopathologically under light microscope for epithelization, inflammation, necrosis, and fibrosis.

RESULTS

The fibrosis indexes of the treated group were significantly less than those of the control group (P < .01).

CONCLUSIONS

Systemically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.

Для цитирования: Ertuğrul E Eylem, Cincik Hakan, Dogru Salim, Cekin Engin, Berber Ufuk, Gungor Atila, Poyrazoğlu I Ethem. Effects of halofuginone on fibrosis formation secondary to experimentally induced subglottic trauma.. The Laryngoscope. 2007. DOI: 10.1097/01.mlg.0000250593.19282.47.

Предметные рубрики MeSH

Animals Cicatrix Epithelium Female Fibrosis Glottis Injections, Intraperitoneal Laryngitis Laryngostenosis Larynx Male Necrosis Piperidines Protein Synthesis Inhibitors Quinazolinones Random Allocation Rats Rats, Sprague-Dawley

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