Neurotransmitter uptake by the central nervous system of fresh-water mussel (Anodonta cygnea L): II. Effects of various drugs, amines and ions.

The high-affinity uptakes of serotonin, dopamine and noradrenaline by the cerebral, pedal and visceral ganglia of fresh-water mussel were inhibited by the presence of other amines. Reserpine was the most potent inhibitor among the drugs tested. Chlorpromazine seemed to be a specific inhibitor of serotonin uptake. It did not affect the accumulation of dopamine and noradrenaline. Ouabain had an inhibitory effect only at relatively high concentrations. Lack of sodium greatly diminished the rates of accumulation of serotonin and dopamine, but had less effect on the uptake of noradrenaline.