[Adaptive mechanisms of circulatory systems in children with pulmonary hypertension syndrome in congenital valvular defect].

To evaluate the condition of the nitrogen oxide system and adaptation reserves in children with pulmonary hypertension syndrome and congenital heart disease, we examined 64 patients aged 3 to 17 years. The examination included standard cardiological tests, measurements of nitrogen oxide metabolites in blood, the activity of oxidant and antioxidant systems. Blood pressure in the right ventricle and pulmonary artery was controlled by invasive (catheterization of heart cavities, monitoring with Swan-Ganz catheter) and noninvasive (ultrasound) methods. We came to the conclusion that the level of nitrogen oxide is associated with the severity of pulmonary hypertension and characterizes the condition of the oxidant and antioxidant systems.