Science (New York, N.Y.) · 2003
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Nisoli Enzo, Clementi Emilio, Paolucci Clara, Cozzi Valeria, Tonello Cristina, Sciorati Clara, Bracale Renata, Valerio Alessandra, Francolini Maura, Moncada Salvador, Carruba Michele O
Аннотация
Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells. This effect of nitric oxide was dependent on guanosine 3',5'-monophosphate (cGMP) and was mediated by the induction of peroxisome proliferator-activated receptor gamma coactivator 1alpha, a master regulator of mitochondrial biogenesis. Moreover, the mitochondrial biogenesis induced by exposure to cold was markedly reduced in brown adipose tissue of endothelial nitric oxide synthase null-mutant (eNOS-/-) mice, which had a reduced metabolic rate and accelerated weight gain as compared to wild-type mice. Thus, a nitric oxide-cGMP-dependent pathway controls mitochondrial biogenesis and body energy balance.
Предметные рубрики MeSH
3T3 Cells8-Bromo Cyclic Adenosine MonophosphateAdipocytesAdipose Tissue, BrownAnimalsCold TemperatureCyclic GMPDNA, MitochondrialDNA-Binding ProteinsEatingEnergy MetabolismFemaleHeLa CellsHigh Mobility Group ProteinsHumansMaleMiceMice, KnockoutMitochondriaMitochondrial ProteinsMotor ActivityNF-E2-Related Factor 1Nitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IINitric Oxide Synthase Type IIINuclear ProteinsNuclear Respiratory FactorsOligonucleotides, AntisenseOxadiazolesOxygen ConsumptionPenicillamineQuinoxalinesRNA, MessengerRatsSignal TransductionTrans-ActivatorsTranscription FactorsU937 CellsWeight Gain