Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2012
Corn oligopeptides protect against early alcoholic liver injury in rats.
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Zhang Feng, Zhang Jiali, Li Yong
Аннотация
BACKGROUND: The present study aimed to investigate the effects of corn oligopeptides (COPs) on early alcoholic liver injury in rats. A total of 70 Wistar rats were randomly assigned to 7 groups, including a normal control group, 3 alcohol control groups (2.0, 4.0 and 6.0 g/kg/BW ethanol), and 3 COP intervention groups (2.0, 4.0 and 6.0 g/kg/BW ethanol, with 900 mg/kg/BW COPs). The study duration lasted for 4 weeks. Serum markers were assayed, and a histopathological examination was conducted.
RESULTS: We found that the COP treatment prevented the elevation of serum aminotransferase and alleviated the hepatic histological damage that was induced by alcohol. In addition, the COPs counteracted the changes in the SOD activity and the MDA content in serum. Furthermore, the COPs ameliorated the abnormal lipid metabolism.
CONCLUSION: These findings suggest that COPs have a significant protective effect on early alcoholic liver injury in rats.
RESULTS: We found that the COP treatment prevented the elevation of serum aminotransferase and alleviated the hepatic histological damage that was induced by alcohol. In addition, the COPs counteracted the changes in the SOD activity and the MDA content in serum. Furthermore, the COPs ameliorated the abnormal lipid metabolism.
CONCLUSION: These findings suggest that COPs have a significant protective effect on early alcoholic liver injury in rats.