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DOI 10.1016/j.fct.2012.03.083

Медицинская библиотека · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2012

Corn oligopeptides protect against early alcoholic liver injury in rats.

Zhang Feng, Zhang Jiali, Li Yong

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

BACKGROUND

The present study aimed to investigate the effects of corn oligopeptides (COPs) on early alcoholic liver injury in rats. A total of 70 Wistar rats were randomly assigned to 7 groups, including a normal control group, 3 alcohol control groups (2.0, 4.0 and 6.0 g/kg/BW ethanol), and 3 COP intervention groups (2.0, 4.0 and 6.0 g/kg/BW ethanol, with 900 mg/kg/BW COPs). The study duration lasted for 4 weeks. Serum markers were assayed, and a histopathological examination was conducted.

RESULTS

We found that the COP treatment prevented the elevation of serum aminotransferase and alleviated the hepatic histological damage that was induced by alcohol. In addition, the COPs counteracted the changes in the SOD activity and the MDA content in serum. Furthermore, the COPs ameliorated the abnormal lipid metabolism.

CONCLUSION

These findings suggest that COPs have a significant protective effect on early alcoholic liver injury in rats.

Для цитирования: Zhang Feng, Zhang Jiali, Li Yong. Corn oligopeptides protect against early alcoholic liver injury in rats.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012. DOI: 10.1016/j.fct.2012.03.083.

Предметные рубрики MeSH

Alanine TransaminaseAmino AcidsAnimalsAspartate AminotransferasesBody WeightCholesterolHepatitis, AlcoholicLipid PeroxidationLipidsLiverLiver Function TestsMaleMalondialdehydeOligopeptidesRatsRats, WistarSuperoxide DismutaseZea mays
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