Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget.

Для цитирования: Fensome Andrew, Bender Reinhold, Chopra Rajiv, Cohen Jeff, Collins Mark A, Hudak Valerie, Malakian Karl, Lockhead Susan, Olland Andrea, Svenson Kristine, Terefenko Eugene A, Unwalla Ray J, Wilhelm James M, Wolfrom Scott, Zhu Yuan, Zhang Zhiming, Zhang Puwen, Winneker Richard C, Wrobel Jay. Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget.. Journal of medicinal chemistry. 2005. DOI: 10.1021/jm050358b.