Ototoxicity and noise-drug interaction.

Diverse therapeutic agents, such as certain antibiotics, diuretics, and analgesics can cause functional and morphological damage to the inner ear. Noise present in recreational or occupational environment may also be potentially damaging to the auditory system when combined with some ototoxic therapeutic agents. This article documents recent research and controversies about the site and mechanism of action of major ototoxic drugs, noise-drug interaction, and possible prophylaxis against such ototoxicity.