Clinical gerontologist · 2026
Caregiver-Targeted Online Multicomponent Intervention and Quality of Life in Alzheimer's Disease: A Randomized Controlled Trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Muñoz-Padros Jordina, Garolera Maite, Puigoriol-Juvanteny Emma, Bartés-Plans Anna, Romero Mas Teresa, Roura-Poch Pere, Foguet-Boreu Quintí
Аннотация
OBJECTIVES: To examine whether a brief, fully online caregiver-targeted multicomponent psychological intervention improves self-reported quality of life (QoL) in people with Alzheimer's disease (AD).
METHODS: In this randomized controlled trial, 56 people with AD and their informal caregivers were assigned to an intervention (n = 28) or usual-care control group (n = 28). Caregivers in the intervention group completed an 8-week online program combining psychoeducation and mindfulness. Outcomes were assessed at baseline and post-intervention by blinded assessors. The primary outcome was QoL assessed with the QoL-AD. Group-by-time effects were analyzed using linear mixed-effects models.
RESULTS: Compared with controls, people with AD in the intervention group showed greater improvement in QoL-AD (p < .001). Neuropsychiatric symptoms worsened in the control group but remained stable in the intervention group (group × time p = .039). No significant effects were observed for cognitive performance.
CONCLUSIONS: A brief caregiver-targeted online intervention was associated with improved QoL and stabilization of neuropsychiatric symptoms in people with AD.
CLINICAL IMPLICATIONS: Trial registration: ClinicalTrials.gov, NCT04280861 (registered 17 February 2020).
METHODS: In this randomized controlled trial, 56 people with AD and their informal caregivers were assigned to an intervention (n = 28) or usual-care control group (n = 28). Caregivers in the intervention group completed an 8-week online program combining psychoeducation and mindfulness. Outcomes were assessed at baseline and post-intervention by blinded assessors. The primary outcome was QoL assessed with the QoL-AD. Group-by-time effects were analyzed using linear mixed-effects models.
RESULTS: Compared with controls, people with AD in the intervention group showed greater improvement in QoL-AD (p < .001). Neuropsychiatric symptoms worsened in the control group but remained stable in the intervention group (group × time p = .039). No significant effects were observed for cognitive performance.
CONCLUSIONS: A brief caregiver-targeted online intervention was associated with improved QoL and stabilization of neuropsychiatric symptoms in people with AD.
CLINICAL IMPLICATIONS: Trial registration: ClinicalTrials.gov, NCT04280861 (registered 17 February 2020).