Медицинская библиотека · Biological psychiatry · 2026

Childhood Maltreatment and Deviations From Normative Brain Structure: A Mega-Analysis of 3711 Individuals From the ENIGMA Major Depressive Disorder and ENIGMA Posttraumatic Stress Disorder Working Groups.

Wang Haley R, Liu Zhen-Qi, Pozzi Elena, Hussain Ahmed, Sigar Priyanka, Abdallah Chadi, Alexander Nina, Baker Justin, Bauer Jochen, Blackford Jennifer Urbano, Cisler Josh, Connolly Colm G, Cotton Andrew, Daniels Judith, Dannlowski Udo, Densmore Maria, deRoon-Cassini Terri, Dima Danai, Du Plessis Stefan, Etkin Amit, Fani Negar, Fisch Lukas, Fitzgerald Jacklynn, Frodl Thomas, Fu Cynthia H Y, Gonul Ali Saffet, Gordon Evan M, Gotlib Ian H, Goya-Maldonado Roberto, Groenewold Nynke A, Grotegerd Dominik, Hahn Tim, Hamilton J Paul, Han Laura K M, Harpaz-Rotem Ilan, Haswell Courtney C, Herringa Ryan, Herzog Julia, Ipser Jonathan, Jahanshad Neda, Jovanovic Tanja, Kaufman Milissa, Kircher Tilo, Konowski Maximilian, Koopowitz Sheri-Michelle, Krug Axel, Krystal John, Lanius Ruth, Larson Christine, Lazarov Amit, Lebois Lauren, Leehr Elisabeth, Levy Ifat, Li Meng, Manthey Antje, Maron-Katz Adi, McIntosh Andrew M, McLaughlin Katie A, Meinert Susanne, Mwangi Benson, Nelson Steven M, Nenadić Igor, Neria Yuval, Neufeld Richard, Ojha Amar, Olatunji Bunmi O, Olson Elizabeth A, Opel Nils, Peverill Matthew, Ressler Kerry, Ross Marisa, Rosso Isabelle, Sacchet Matthew D, Sambrook Kelly, Schmahl Christian, Seedat Soraya, Shenton Martha E, Sicorello Maurizio, Sierk Anika, Soares Jair C, Stein Dan J, Stein Frederike, Stein Murray B, Suarez-Jimenez Benjamin, Théberge Jean, Thomopoulos Sophia I, Tomas Carissa, Usemann Paula, van den Heuvel Leigh L, van Rooij Sanne J H, Walter Henrik, Walter Martin, Wang Xin, Whalley Heather C, Winter Nils R, Wu Mon-Ju, Xie Hong, Yang Tony T, Zhu Xi, Zilcha-Mano Sigal, Zunta-Soares Giovana B, Frangou Sophia, Thompson Paul M, Salminen Lauren, Sun Delin, Morey Rajendra, Stevens Jennifer S, Schmaal Lianne, Ho Tiffany C

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Аннотация

BACKGROUND

Childhood maltreatment (CM), encompassing abuse and neglect, is highly prevalent and associated with elevated risk for major depressive disorder (MDD), posttraumatic stress disorder (PTSD), and other related conditions. However, the extent to which neuroanatomical alterations in MDD and PTSD are attributable to CM is uncertain.

METHODS

Here, we analyzed CM and whole-brain magnetic resonance imaging (MRI) data from 3711 participants in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) MDD and PTSD Working Groups (25 sites; mean age = 33.3 ± 13.0 years; 59.9% female). Normative modeling estimated deviation z scores for 14 subcortical volume, 68 cortical thickness (CT), and 68 surface area (SA) measures. To identify transdiagnostic effects, associations between CM and brain deviation scores were evaluated across all participants (patients and healthy control participants) stratified by sex and 3 age bins (pediatric, young adult, older adult).

RESULTS

In young adults (ages 18-35), abuse was associated with larger volumes in the thalamus and pallidum, thinner isthmus cingulate and middle frontal regions, and thicker medial orbitofrontal cortex; there were no significant effects in pediatric (≤18 years) participants. The strongest effects were observed in young female adults (|β| = 0.07-0.22, q < .05): Greater abuse and neglect were correlated with smaller hippocampus and putamen volumes, thinner entorhinal cortex, and smaller SA in fusiform/inferior parietal regions and with larger SA in the orbitofrontal and occipital cortices. In males, abuse had widespread effects on CT and SA (|β| = 0.1-0.18, q < .05); effects for neglect were minimal.

CONCLUSIONS

Our findings of age- and sex-specific instantiations of CM on brain morphometry highlight the importance of developmental context in understanding how adverse experiences shape neurobiological vulnerability to MDD and PTSD.

Для цитирования: Wang Haley R, Liu Zhen-Qi, Pozzi Elena, Hussain Ahmed, Sigar Priyanka, Abdallah Chadi, Alexander Nina, Baker Justin, Bauer Jochen, Blackford Jennifer Urbano, Cisler Josh, Connolly Colm G, Cotton Andrew, Daniels Judith, Dannlowski Udo, Densmore Maria, deRoon-Cassini Terri, Dima Danai, Du Plessis Stefan, Etkin Amit, Fani Negar, Fisch Lukas, Fitzgerald Jacklynn, Frodl Thomas, Fu Cynthia H Y, Gonul Ali Saffet, Gordon Evan M, Gotlib Ian H, Goya-Maldonado Roberto, Groenewold Nynke A, Grotegerd Dominik, Hahn Tim, Hamilton J Paul, Han Laura K M, Harpaz-Rotem Ilan, Haswell Courtney C, Herringa Ryan, Herzog Julia, Ipser Jonathan, Jahanshad Neda, Jovanovic Tanja, Kaufman Milissa, Kircher Tilo, Konowski Maximilian, Koopowitz Sheri-Michelle, Krug Axel, Krystal John, Lanius Ruth, Larson Christine, Lazarov Amit, Lebois Lauren, Leehr Elisabeth, Levy Ifat, Li Meng, Manthey Antje, Maron-Katz Adi, McIntosh Andrew M, McLaughlin Katie A, Meinert Susanne, Mwangi Benson, Nelson Steven M, Nenadić Igor, Neria Yuval, Neufeld Richard, Ojha Amar, Olatunji Bunmi O, Olson Elizabeth A, Opel Nils, Peverill Matthew, Ressler Kerry, Ross Marisa, Rosso Isabelle, Sacchet Matthew D, Sambrook Kelly, Schmahl Christian, Seedat Soraya, Shenton Martha E, Sicorello Maurizio, Sierk Anika, Soares Jair C, Stein Dan J, Stein Frederike, Stein Murray B, Suarez-Jimenez Benjamin, Théberge Jean, Thomopoulos Sophia I, Tomas Carissa, Usemann Paula, van den Heuvel Leigh L, van Rooij Sanne J H, Walter Henrik, Walter Martin, Wang Xin, Whalley Heather C, Winter Nils R, Wu Mon-Ju, Xie Hong, Yang Tony T, Zhu Xi, Zilcha-Mano Sigal, Zunta-Soares Giovana B, Frangou Sophia, Thompson Paul M, Salminen Lauren, Sun Delin, Morey Rajendra, Stevens Jennifer S, Schmaal Lianne, Ho Tiffany C. Childhood Maltreatment and Deviations From Normative Brain Structure: A Mega-Analysis of 3711 Individuals From the ENIGMA Major Depressive Disorder and ENIGMA Posttraumatic Stress Disorder Working Groups.. Biological psychiatry. 2026. DOI: 10.1016/j.biopsych.2026.02.016.

Предметные рубрики MeSH

Humans Female Major Depressive Disorder Male Magnetic Resonance Imaging Brain Adult Adolescent Stress Disorders, Post-Traumatic Young Adult Child Abuse Adult Survivors of Child Abuse Child Middle Aged

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