Japanese journal of infectious diseases · 2010
Molecular and virological analyses of dengue virus responsible for dengue outbreak in East Timor in 2005.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ito Mikako, Takasaki Tomohiko, Kotaki Akira, Tajima Shigeru, Yuwono Djoko, Rimal Hem Sagar, dos Santos Filipe, de Jesus Maria Dolores, Lina Bernadina Bano, Tsuda Yoshio, Lim Chang-Kweng, Nerome Reiko, Calerés Antonio, Shindo Nahoko, Drager Renu Dayal, Andjaparidze Alex, Kurane Ichiro
Аннотация
A severe dengue outbreak occurred in East Timor in 2005. The dengue virus genome was detected by TaqMan RT-PCR in 40 serum samples, as follows: dengue virus type-3 (DENV-3) in 37 samples, DENV-2 in 2 samples, and DENV-1 in one sample. One DENV-1 genome, one DENV-2 genome, and 5 DENV-3 genomes were sequenced, and these specimens were aligned with the previously determined envelope (E) gene sequences. The DENV-1 strain belonged to genotype IV and was close to those previously isolated in Indonesia and Australia. The DENV-2 strain belonged to genotype I and was close to those previously isolated in Indonesia, Australia, the Far East, and India in 1993-2001. The DENV-3 strain belonged to genotype I and was close to those previously isolated in Indonesia. The results indicate that the dengue outbreak was caused mainly by DENV-3, with DENV-1 and DENV-2 as minor serotypes, and suggest that these strains of 3 serotypes of DENV entered East Timor from neighboring countries, co-circulated, and caused the dengue outbreak in 2005.