Polychlorinated biphenyls and organochlorines pesticides in indoor dust: An exploration of sources and health exposure risk in a rural area (Kopawa) of Nepal.

While contamination of indoor environment with organochlorine compounds (OCs) is well documented worldwide, only a few studies highlighted the problem of indoor pollution in Indian sub-continent, including Nepal. This study insight the contamination level, distribution pattern, and sources of OCs in indoor dust from a rural area of Nepal. Additionally, daily exposure risk through different intake pathways was estimated in order to mark the potential risk of OCs to local residents. Results indicated the predominance of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in dust. Ʃ26OCPs (median 87 ng/g) in dust was about 7-8 times greater than Ʃ30PCBs (median 10.5 ng/g). DDT was the most abundant chemical among Ʃ26OCPs, followed by HCHs and endosulfan, and accounted for 73%, 7%, and 4% of Ʃ26OCPs, respectively. A relatively high level of ƩDDT than other OCPs suggests the existence of DDT source in the Nepalese environment. Among PCB, tetra-CBs were most prevalent, trailed by penta-CBs, hexa-CBs, and hepta-CBs, and comprised 28%, 21%, 17% and 17% of Ʃ30PCBs, respectively. Dioxin like-PCBs (median 3.48 ng/g) was about two times higher than the total indicator-PCB (median 1.63 ng/g). High p,p-DDT/p,p-DDE ratio (median 2.89) suggested fresh application and minimal degradation of DDT in the local environment of Kopawa. While lower α-/γ-HCH ratio (median 0.75) indicated lindane contamination as the primary sources of HCH. Moreover, the low α-/β-endosulfan ratio (median 0.86) specified the fresh use of commercial endosulfan. Among OCPs, only DDT positively related to total organic carbon (TOC) (Rho = 0.55, p < 0.05) but not black carbon (BC), proposing minimal or zero impact of TOC and BC. For PCBs, PCB-126 was moderately and negatively correlated with TOC (Rho = -0.49, p < 0.05), but not BC. The daily risk exposure (DRE) assessment showed that children are more vulnerable to OCs than the adult. The DRE of OCs in this study were 2-4 order of magnitude lower than their corresponding reference dose (RfD), proposing insignificant risk.