International journal of obesity (2005) · 2026
Life stage-specific heterogeneity in the effects of adiposity transition on hypertension incidence and resolution.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Meng Xin, Chen Linlin, Qi QianJin, Liu Wei, Xue Yongxi, Yan Yinkun
Аннотация
OBJECTIVE: Whether the effects of excess adiposity on the onset and resolution of hypertension and its subtypes differ across different life stages remains unclear. We aimed to explore age-related heterogeneity in the associations of excess adiposity transition with hypertension development and resolution over the life course in Chinese population.
METHODS: This dynamic cohort study included 24,104 participants aged 3 to 80 years from the China Health and Nutrition Survey. We calculated the odd ratios (ORs) and confidence intervals (CIs) of excess adiposity at baseline and adiposity status transition during follow-up associated with hypertension using generalized linear mix-effects model.
RESULTS: High body mass index (BMI) at baseline showed the strongest association with hypertension incidence in early adulthood (OR 2.29, 95% CI 2.14-2.45), while high waist circumference (WC) showed the strongest association in childhood (OR 3.14, 95% CI 1.75-5.20). Participants transitioning from normal to high BMI/WC had increased hypertension incidence risks across all age groups, with the strongest association observed in the 3-17 year group (BMI, OR = 2.08, 95% CI = 1.42-2.96; WC, OR = 3.41, 95% CI = 2.26-4.97). In comparison, participants transitioning from high BMI/WC to normal BMI/WC had the strongest association in the 3-17 year group for BMI (OR = 4.73, 95% CI = 0.50-57.5) and in the 18-40 year group for WC (OR = 2.52, 95% CI = 1.48-4.44).
CONCLUSION: This study demonstrated life stage-specific heterogeneity in the effects of excess adiposity on hypertension, with individuals in childhood and early life conferring stronger influences. These results underscore the importance of considering age-specific approaches to weight management for hypertension prevention and control.
METHODS: This dynamic cohort study included 24,104 participants aged 3 to 80 years from the China Health and Nutrition Survey. We calculated the odd ratios (ORs) and confidence intervals (CIs) of excess adiposity at baseline and adiposity status transition during follow-up associated with hypertension using generalized linear mix-effects model.
RESULTS: High body mass index (BMI) at baseline showed the strongest association with hypertension incidence in early adulthood (OR 2.29, 95% CI 2.14-2.45), while high waist circumference (WC) showed the strongest association in childhood (OR 3.14, 95% CI 1.75-5.20). Participants transitioning from normal to high BMI/WC had increased hypertension incidence risks across all age groups, with the strongest association observed in the 3-17 year group (BMI, OR = 2.08, 95% CI = 1.42-2.96; WC, OR = 3.41, 95% CI = 2.26-4.97). In comparison, participants transitioning from high BMI/WC to normal BMI/WC had the strongest association in the 3-17 year group for BMI (OR = 4.73, 95% CI = 0.50-57.5) and in the 18-40 year group for WC (OR = 2.52, 95% CI = 1.48-4.44).
CONCLUSION: This study demonstrated life stage-specific heterogeneity in the effects of excess adiposity on hypertension, with individuals in childhood and early life conferring stronger influences. These results underscore the importance of considering age-specific approaches to weight management for hypertension prevention and control.