First successful treatment of phaeohyphomycosis due to Medicopsis romeroi with isavuconazole in a renal transplant recipient in France.

OBJECTIVES

We report a case of Medicopsis romeroi phaeohyphomycosis in a 25-year-old Malian patient residing in France for 4 years. He developed lesions on his right foot 6 months after receiving immunosuppressive therapy for a renal transplant.

METHODES: Microscopic examination of the biopsy revealed septate hyphae, and the culture grew a black mold without fructification, thereby enabling identification. The diagnosis was made with molecular tools, and therapy was initiated with isavuconazole.

RESULTS

This case is the first reported successful use of isavuconazole for this pathogen.

CONCLUSION

Clinicians and biologists should be aware of the risk of infection with dematiaceous fungi in solid organ transplant patients from tropical areas.