Journal of psychosomatic research · 2010
Aftermath of sexual abuse history on adult patients suffering from chronic functional pain syndromes: an fMRI pilot study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Noll-Hussong Michael, Otti Alexander, Laeer Leonhard, Wohlschlaeger Afra, Zimmer Claus, Lahmann Claas, Henningsen Peter, Toelle Thomas, Guendel Harald
Аннотация
OBJECTIVE: This preliminary study investigates the neural substrates of empathy-induced pain in multisomatoform pain patients "with vs. without" a history of sexual abuse during childhood.
METHODS: Using functional magnetic resonance imaging (fMRI) and behavioral measurements, we compared eight abused with eight nonabused patients using an established empathy-for-pain paradigm.
RESULTS: Higher activations in left lateral and medial superior frontal gyrus as well as a nonsignificant activation of the right supplementary motor area in abused patients were detected. The nonabused participants showed higher activation of left hippocampus. There was no significant difference in subjective pain ratings between the groups.
CONCLUSION: Although the number of participants still needs to be increased, our main findings mirror the clinical impression and support the notion of perturbed neuroprocessing of grievous stimuli in chronic pain patients with a history of sexual abuse.
METHODS: Using functional magnetic resonance imaging (fMRI) and behavioral measurements, we compared eight abused with eight nonabused patients using an established empathy-for-pain paradigm.
RESULTS: Higher activations in left lateral and medial superior frontal gyrus as well as a nonsignificant activation of the right supplementary motor area in abused patients were detected. The nonabused participants showed higher activation of left hippocampus. There was no significant difference in subjective pain ratings between the groups.
CONCLUSION: Although the number of participants still needs to be increased, our main findings mirror the clinical impression and support the notion of perturbed neuroprocessing of grievous stimuli in chronic pain patients with a history of sexual abuse.