Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2023
Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Franco Filho Luciano Chaves, Barata Rafael Ribeiro, Coelho Mônica Silva, Cardoso Jedson Ferreira, Lemos Poliana da Silva, Dos Reis Herald Souza, Favacho Joana da Felicidade Ribeiro, Faria Nuno Rodrigues, Nunes Marcio Roberto Teixeira
Аннотация
The existence of sylvatic transmission of dengue virus in communities of neotropical bats remains uncertain. In this work we present a near-complete genome of dengue virus serotype 4 obtained from the brain sample of a bat from Platyrrhinus helleri specie collected in the Brazilian Amazon region. The presence of the virus in the brain sample may indicate a possible tropism for the central nervous system in bats, which may justify negative results in previous studies that focused on analysis of other tissues, such as liver and spleen. Besides the duration of dengue virus circulation in the Americas (circa 40 years) may be too short for an implementation of a sylvatic dengue virus cycle. Our findings suggest that continued monitoring is needed to confirm with the neotropical bats could potentially act as a natural reservoir of dengue in the region.