Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica · 2004
[Primary research of pharmacological effects of PEC on mice].
СтатьяНазвание и аннотация: Перевод в очереди
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Wang Li-wei, Liu Xin-min, Lu Guang-hua, Gao Nan-nan, Xiao Pei-gen
Аннотация
OBJECTIVE: To study pharmacological effects of PEC (the oral liquid which consists of Panax quinquefolium, Epimedium brevicornum, Schisandra chinensis Bail and Cervus eplaphus) on mice.
METHOD: Experiments were carried out through swimming test, step-through, spontaneous activity and sleeping time.
RESULT: When 5-10 mL x kg(-1) of PEC was given orally for 7 days, it could prolong swimming duration of mice in water tank, and increase the tolerant ability against oxygen-deficiency. PEC could also improve cognitive-deficiency induced by taking off sleep with force in mice after given orally for 7 days. The PEC could increase the spontaneous activity in mice, antagonize the inhabitation induced by Valium, and shorten the sleeping time caused by sodium pentobarbital.
CONCLUSION: PEC has strong potential neuro-pharmacological activities such as anti-fatigue, improving cognitive-deficiency in mice.
METHOD: Experiments were carried out through swimming test, step-through, spontaneous activity and sleeping time.
RESULT: When 5-10 mL x kg(-1) of PEC was given orally for 7 days, it could prolong swimming duration of mice in water tank, and increase the tolerant ability against oxygen-deficiency. PEC could also improve cognitive-deficiency induced by taking off sleep with force in mice after given orally for 7 days. The PEC could increase the spontaneous activity in mice, antagonize the inhabitation induced by Valium, and shorten the sleeping time caused by sodium pentobarbital.
CONCLUSION: PEC has strong potential neuro-pharmacological activities such as anti-fatigue, improving cognitive-deficiency in mice.