Characteristics and Outcomes of Over 300,000 Patients with COVID-19 and History of Cancer in the United States and Spain.
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Roel Elena, Pistillo Andrea, Recalde Martina, Sena Anthony G, Fernández-Bertolín Sergio, Aragón Maria, Puente Diana, Ahmed Waheed-Ul-Rahman, Alghoul Heba, Alser Osaid, Alshammari Thamir M, Areia Carlos, Blacketer Clair, Carter William, Casajust Paula, Culhane Aedin C, Dawoud Dalia, DeFalco Frank, DuVall Scott L, Falconer Thomas, Golozar Asieh, Gong Mengchun, Hester Laura, Hripcsak George, Tan Eng Hooi, Jeon Hokyun, Jonnagaddala Jitendra, Lai Lana Y H, Lynch Kristine E, Matheny Michael E, Morales Daniel R, Natarajan Karthik, Nyberg Fredrik, Ostropolets Anna, Posada José D, Prats-Uribe Albert, Reich Christian G, Rivera Donna R, Schilling Lisa M, Soerjomataram Isabelle, Shah Karishma, Shah Nigam H, Shen Yang, Spotniz Matthew, Subbian Vignesh, Suchard Marc A, Trama Annalisa, Zhang Lin, Zhang Ying, Ryan Patrick B, Prieto-Alhambra Daniel, Kostka Kristin, Duarte-Salles Talita
Аннотация
METHODS: We conducted a cohort study using eight routinely collected health care databases from Spain and the United States, standardized to the Observational Medical Outcome Partnership common data model. Three cohorts of patients with a history of cancer were included: (i) diagnosed with COVID-19, (ii) hospitalized with COVID-19, and (iii) hospitalized with influenza in 2017 to 2018. Patients were followed from index date to 30 days or death. We reported demographics, cancer subtypes, comorbidities, and 30-day outcomes.
RESULTS: We included 366,050 and 119,597 patients diagnosed and hospitalized with COVID-19, respectively. Prostate and breast cancers were the most frequent cancers (range: 5%-18% and 1%-14% in the diagnosed cohort, respectively). Hematologic malignancies were also frequent, with non-Hodgkin's lymphoma being among the five most common cancer subtypes in the diagnosed cohort. Overall, patients were aged above 65 years and had multiple comorbidities. Occurrence of death ranged from 2% to 14% and from 6% to 26% in the diagnosed and hospitalized COVID-19 cohorts, respectively. Patients hospitalized with influenza (n = 67,743) had a similar distribution of cancer subtypes, sex, age, and comorbidities but lower occurrence of adverse events.
CONCLUSIONS: Patients with a history of cancer and COVID-19 had multiple comorbidities and a high occurrence of COVID-19-related events. Hematologic malignancies were frequent.
IMPACT: This study provides epidemiologic characteristics that can inform clinical care and etiologic studies.