Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2006
Outcome of secondary high-grade glioma in children previously treated for a malignant condition: a study of the Canadian Pediatric Brain Tumour Consortium.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Carret Anne-Sophie, Tabori Uri, Crooks Bruce, Hukin Juliette, Odame Isaac, Johnston Donna L, Keene Daniel L, Freeman Carolyn, Bouffet Eric, Canadian Pediatric Brain Tumour Consortium
Аннотация
BACKGROUND AND PURPOSE: Reports of secondary high-grade glioma (HGG) in survivors of childhood cancer are scarce. The aim of this study was to review the pattern of diagnosis, the treatment, and outcome of secondary pediatric HGG.
PATIENTS AND METHODS: We performed a multi-center retrospective study among the 17 paediatric institutions participating in the Canadian Pediatric Brain Tumour Consortium (CPBTC).
RESULTS: We report on 18 patients (14 males, 4 females) treated in childhood for a primary cancer, who subsequently developed a HGG as a second malignancy. All patients had previously received radiation therapy +/- chemotherapy for either acute lymphoblastic leukaemia (n=9) or solid tumour (n=9). All HGG occurred within the previous radiation fields. At the last follow-up, 17 patients have died and the median survival time is 9.75 months.
CONCLUSION: Although aggressive treatment seems to provide sustained remissions in some patients, the optimal management is still to be defined. Further documentation of such cases is necessary in order to better understand the pathogenesis, the natural history and the prevention of these tumours.
PATIENTS AND METHODS: We performed a multi-center retrospective study among the 17 paediatric institutions participating in the Canadian Pediatric Brain Tumour Consortium (CPBTC).
RESULTS: We report on 18 patients (14 males, 4 females) treated in childhood for a primary cancer, who subsequently developed a HGG as a second malignancy. All patients had previously received radiation therapy +/- chemotherapy for either acute lymphoblastic leukaemia (n=9) or solid tumour (n=9). All HGG occurred within the previous radiation fields. At the last follow-up, 17 patients have died and the median survival time is 9.75 months.
CONCLUSION: Although aggressive treatment seems to provide sustained remissions in some patients, the optimal management is still to be defined. Further documentation of such cases is necessary in order to better understand the pathogenesis, the natural history and the prevention of these tumours.
Предметные рубрики MeSH
AdolescentAdultAstrocytomaBrain NeoplasmsCanadaChildCranial IrradiationFemaleGliomaHumansMaleNeoplasmsNeoplasms, Radiation-InducedNeoplasms, Second PrimaryPrecursor Cell Lymphoblastic Leukemia-LymphomaRemission InductionRetrospective StudiesStatistics, NonparametricSurvival AnalysisTreatment Outcome