The American journal of tropical medicine and hygiene · 2022
Diagnosis of Acute Chagas Disease in a Belizean Child with Evidence of a Multiclonal Trypanosoma cruzi Infection.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Murray Kristy O, Saldaña Miguel A, Gunter Sarah M, Manzanero Russell, Zielinski-Gutierrez Emily, Herrera Claudia, Thompson Julie M, Maliga Adrianna, Bautista Kim, Lino Allison, Hawes Ella, Ronca Shannon E, Morey Francis, Fuentes Rafael Chacon, Lopez Beatriz, Dumonteil Eric, Morazan Gerhaldine H
Аннотация
In January 2020, we instituted acute febrile illness surveillance in 11 hospitals and clinics across Belize. Within 3 months, we diagnosed an acute case of Chagas disease by polymerase chain reaction in a 7-year-old child in the northern part of the country. Phylogenetic analyses of the parasite from the acute blood specimen revealed a multiclonal Trypanosoma cruzi infection, including parasites from the TcII (25.0% of haplotypes), TcIV (2.5% of haplotypes), and TcV (72.5% of haplotypes) discrete typing units. The family reported no history of travel, and three Triatoma species vectors were found within the home. The child's mother was seronegative for antibodies to T. cruzi, ruling out congenital transmission. Convalescent blood samples documented seroconversion and confirmed acute infection. The child was successfully treated with nifurtimox. This is the first known diagnosed case of acute Chagas infection in Belize, highlighting the need for further investigation and public health prevention measures.