Journal of dentistry · 2025
Incorporation of polymethyl methacrylate (PMMA) - cerium (Ce) nanofibers into acrylic resin for removable denture bases: evaluation of physical-mechanical properties, cytotoxicity, and antifungal activity.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Rangel Bianca Tavares, Costa Mylena Proença, Farias Rosiane Maria da Costa, Figueiredo Lucas Ricardo Fernandes, Dias Rebeca Tibau Aguiar, de Medeiros Eliton Souto, Porto Vinicius Carvalho, Soares Simone, Urban Vanessa Migliorini, Soares Diana Gabriela, Menezes Romualdo Rodrigues, Batista André Ulisses Dantas, Neppelenbroek Karin Hermana
Аннотация
OBJECTIVE: This study aimed to synthesize and characterize polymethyl methacrylate (PMMA) - cerium (Ce) nanofibers and investigate the effect of their incorporation on the biological, physical-mechanical properties and cytotoxicity of PMMA acrylic resin for removable denture bases.
METHODS: PMMA-Ce nanofibers produced by solution blown spinning with different concentrations of Ce (5%, 10%, 15%, and 20%) were evaluated for activity against Candida albicans and characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, thermogravimetry, differential scanning calorimetry, and inductively coupled plasma optical emission spectroscopy (ICP-OES). Different proportions of nanofibers (0, 0.5, 1, 2.5, and 5 wt%) were incorporated into PMMA and characterized by SEM, ICP-OES, and thermogravimetry. Samples were evaluated for antifungal activity, flexural strength, Knoop microhardness, surface roughness, contact angle, color parameters (L*, a*, and b*), and cytotoxicity. Data were analyzed using Kruskal-Wallis and Dwass-Steel-Chritchlow-Fligner tests or ANOVA and Tukey test (α=0.05).
RESULTS: The 15% nanofibers showed antifungal activity (p < 0.05) and released Ce ions for 14 days. PMMA modified by 15% nanofibers did not show antifungal activity (p > 0.05) or release Ce ions. The nanofibers reduced the flexural strength and changed the color of the modified resin in proportions of 2.5% and 5% while decreasing its hardness in proportions of 0.5% and 5%. Regardless of the proportion, the nanofibers increased the PMMA contact angle (p < 0.05), without altering roughness and cytotoxicity of the acrylic resin (p > 0.05).
SIGNIFICANCE: The incorporation of PMMA-Ce nanofibers into PMMA resulted in no antifungal activity and affected the physical-mechanical properties of the modified material, without altering its cytotoxicity.
METHODS: PMMA-Ce nanofibers produced by solution blown spinning with different concentrations of Ce (5%, 10%, 15%, and 20%) were evaluated for activity against Candida albicans and characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, thermogravimetry, differential scanning calorimetry, and inductively coupled plasma optical emission spectroscopy (ICP-OES). Different proportions of nanofibers (0, 0.5, 1, 2.5, and 5 wt%) were incorporated into PMMA and characterized by SEM, ICP-OES, and thermogravimetry. Samples were evaluated for antifungal activity, flexural strength, Knoop microhardness, surface roughness, contact angle, color parameters (L*, a*, and b*), and cytotoxicity. Data were analyzed using Kruskal-Wallis and Dwass-Steel-Chritchlow-Fligner tests or ANOVA and Tukey test (α=0.05).
RESULTS: The 15% nanofibers showed antifungal activity (p < 0.05) and released Ce ions for 14 days. PMMA modified by 15% nanofibers did not show antifungal activity (p > 0.05) or release Ce ions. The nanofibers reduced the flexural strength and changed the color of the modified resin in proportions of 2.5% and 5% while decreasing its hardness in proportions of 0.5% and 5%. Regardless of the proportion, the nanofibers increased the PMMA contact angle (p < 0.05), without altering roughness and cytotoxicity of the acrylic resin (p > 0.05).
SIGNIFICANCE: The incorporation of PMMA-Ce nanofibers into PMMA resulted in no antifungal activity and affected the physical-mechanical properties of the modified material, without altering its cytotoxicity.
Предметные рубрики MeSH
Polymethyl MethacrylateCandida albicansDenture BasesNanofibersMaterials TestingAcrylic ResinsCeriumAntifungal AgentsHardnessSurface PropertiesFlexural StrengthMicroscopy, Electron, ScanningSpectroscopy, Fourier Transform InfraredDental MaterialsColorHumansThermogravimetryCalorimetry, Differential ScanningAnimalsCell SurvivalDenture, Partial, RemovablePliability