Dementia and geriatric cognitive disorders · 2010
Neuropsychological predictors of dementia in a three-year follow-up period: data from the LADIS study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Madureira Sofia, Verdelho Ana, Moleiro Carla, Ferro José M, Erkinjuntti Timo, Jokinen Hanna, Pantoni Leonardo, Fazekas Franz, Van der Flier Wiesje, Visser Marieke, Waldemar Gunhild, Wallin Anders, Hennerici Michael, Inzitari Domenico
Аннотация
BACKGROUND: White matter changes (WMC) are related to cognitive deficits and dementia. Our aim was to determine the extent to which the performance in neuropsychological tests would be able to predict the clinical diagnosis of dementia.
METHODS: The LADIS (Leukoaraiosis and Disability) is a prospective study that evaluates the impact of WMC on the transition of independent elderly to disability. The subjects were evaluated at baseline and yearly during 3 years with a comprehensive clinical, functional and neuropsychological protocol. At each visit, dementia was classified according to clinical criteria. The performance in the neuropsychological batteries was compared according to the clinical diagnosis of dementia.
RESULTS: From the initially enrolled 639 subjects, 480 were evaluated at year 3. Dementia was diagnosed in 90 participants. The demented subjects had worse performance in almost all the baseline cognitive tests. Using receiver operating characteristic curves, we found that the Vascular Dementia Assessment Scale (VADAS) battery had higher sensitivity and specificity rates (area under the curve = 82%) to identify dementia compared with the Mini-Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale. Worse performance on baseline MMSE (beta = 0.33; p < 0.001) and VADAS (beta = -0.07; p = 0.02) were predictors of dementia (regression analyses).
CONCLUSION: Performance on the MMSE and the VADAS battery were important predictors of dementia at a 3-year period.
METHODS: The LADIS (Leukoaraiosis and Disability) is a prospective study that evaluates the impact of WMC on the transition of independent elderly to disability. The subjects were evaluated at baseline and yearly during 3 years with a comprehensive clinical, functional and neuropsychological protocol. At each visit, dementia was classified according to clinical criteria. The performance in the neuropsychological batteries was compared according to the clinical diagnosis of dementia.
RESULTS: From the initially enrolled 639 subjects, 480 were evaluated at year 3. Dementia was diagnosed in 90 participants. The demented subjects had worse performance in almost all the baseline cognitive tests. Using receiver operating characteristic curves, we found that the Vascular Dementia Assessment Scale (VADAS) battery had higher sensitivity and specificity rates (area under the curve = 82%) to identify dementia compared with the Mini-Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale. Worse performance on baseline MMSE (beta = 0.33; p < 0.001) and VADAS (beta = -0.07; p = 0.02) were predictors of dementia (regression analyses).
CONCLUSION: Performance on the MMSE and the VADAS battery were important predictors of dementia at a 3-year period.
Предметные рубрики MeSH
AgedAged, 80 and overAgingBrainCognition DisordersDementiaDementia, VascularPersons with DisabilitiesDisease ProgressionFollow-Up StudiesHumansInternationalityLongitudinal StudiesNeuropsychological TestsPredictive Value of TestsProspective StudiesPsychiatric Status Rating ScalesROC CurveSensitivity and Specificity