Hearing research · 1997
Age-related decline of auditory function in the chinchilla (Chinchilla laniger).
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
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McFadden S L, Campo P, Quaranta N, Henderson D
Аннотация
The aim of this study was to examine the functional consequences of aging in the chinchilla, a rodent with a relatively long life span and a range of hearing similar to that of humans. Subjects were 21 chinchillas aged 10-15 years, and 23 young controls. Thresholds were determined from auditory evoked potentials (EVPs), and outer hair cell (OHC) functioning was assessed by measuring 2f1-f2 distortion product otoacoustic emissions (DPOAEs). Six cochleas from 11-12-year-old animals were examined for hair cell loss and gross strial pathology. The results show that the chinchilla exhibits a small but significant decline of auditory sensitivity and OHC functioning between 3 and 15 years of age, with high-frequency losses exceeding and growing more rapidly than low-frequency losses. Compared to rodents with shorter life spans, the chinchilla has a rate of loss that is more similar to that of humans, which could make it a valuable model for understanding the etiology of human presbycusis.