Pest management science · 2026
Hypogin-derived N-cinnamoylated peptide as a promising green fungicide against peanut southern blight caused by Sclerotium rolfsii.
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Li Guangyao, Zhou Lin, Wang Qiya, Ren Yayu, Song Yaru, Mao Xuewei, Wang Meizi
Аннотация
BACKGROUND: Peanut southern blight, caused by Sclerotium rolfsii, severely reduces yield and quality. The overuse of chemical fungicides accelerates resistance development and raises environmental concerns, highlighting the necessity for eco-friendly alternatives. Hypogin is an endogenous peanut peptide with broad-spectrum antifungal activity. This study aims to identify the active centers of hypogin and evaluate the antifungal activity and preliminary mechanisms of its derived peptides.
RESULTS: Seven hypogin-derived peptides (series I) and two cinnamic acid conjugates (series II) were synthesized. Among these, II-1 (cinnamic-KSPY-NH2) demonstrated the highest in vitro activity against S. rolfsii, with a half-maximal effective concentration value of 257.93 mg/L. In vivo studies revealed that II-1 provided superior curative efficacy (66.47%) against peanut southern blight, surpassing the commercial fungicide polyoxin (57.33%), and also promoted root growth in peanuts. Both I-7 and II-1 exhibited low cytotoxicity toward human LO2 liver cells, with inhibition rates of 5.05% and 17.44%, respectively, at a concentration of 400 mg/L. Preliminary mechanistic investigations indicated that I-7 specifically targets the Vps34 signaling pathway in S. rolfsii.
CONCLUSION: Hypogin-derived peptide II-1 exhibits significant antifungal activity and low toxicity, making it a promising candidate for a green fungicide in the management of peanut southern blight. © 2026 Society of Chemical Industry.
RESULTS: Seven hypogin-derived peptides (series I) and two cinnamic acid conjugates (series II) were synthesized. Among these, II-1 (cinnamic-KSPY-NH2) demonstrated the highest in vitro activity against S. rolfsii, with a half-maximal effective concentration value of 257.93 mg/L. In vivo studies revealed that II-1 provided superior curative efficacy (66.47%) against peanut southern blight, surpassing the commercial fungicide polyoxin (57.33%), and also promoted root growth in peanuts. Both I-7 and II-1 exhibited low cytotoxicity toward human LO2 liver cells, with inhibition rates of 5.05% and 17.44%, respectively, at a concentration of 400 mg/L. Preliminary mechanistic investigations indicated that I-7 specifically targets the Vps34 signaling pathway in S. rolfsii.
CONCLUSION: Hypogin-derived peptide II-1 exhibits significant antifungal activity and low toxicity, making it a promising candidate for a green fungicide in the management of peanut southern blight. © 2026 Society of Chemical Industry.