Pediatric radiology · 2024
Rapid and motion-robust pediatric brain imaging: T2-weighted turbo-spin-echo PROPELLER acquisition with compressed sensing.
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Wichtmann Barbara Daria, Katemann Christoph, Kadrija Mergim, Layer Yannik C, Bischoff Leon M, Scheuver Yvonne, Mezger Madeleine, Weber Oliver M, Luetkens Julian A, Attenberger Ulrike I, Radbruch Alexander, Paech Daniel
Аннотация
BACKGROUND: In pediatric magnetic resonance imaging (MRI), reducing the rate of non-diagnostic scans due to artifacts and shortening acquisition time are crucial not only for economic reasons but also to minimize sedation or general anesthesia.
OBJECTIVE: Enabling faster and motion-robust MRI of the brain in infants and children using a novel, enhanced compressed sensing (CS) algorithm in combination with a turbo-spin-echo T2-weighted sequence utilizing the PROPELLER-technique (periodically rotated overlapping parallel lines with enhanced reconstruction; T2PROPELLER CS).
MATERIALS AND METHODS: This prospective study included 31 patients (8.0 ± 4.7 years, 15 males) undergoing a clinically indicated MRI examination of the brain on a 3-T scanner. The T2PROPELLER CS sequence was compared to a conventional, CS-accelerated Cartesian turbo-spin-echo T2-weighted sequence (T2Cartesian CS). Apparent contrast-to-noise ratio (aCNR) and signal-to-noise ratio (aSNR) were calculated. Three blinded radiologists independently rated both sequences twice qualitatively on a 5-point Likert-scale from 1-5 (non-diagnostic-excellent) for artifacts, image sharpness, basal ganglia delineation, lesion conspicuity, and overall image quality. Statistical analysis was performed using the Wilcoxon signed-rank test and paired sample t test. Intra- and interrater reliability of qualitative image assessment was evaluated by computing Krippendorff's α reliability estimates.
RESULTS: The average acquisition time of the T2PROPELLER CS (189 ± 27 s) was 31% shorter than that of the T2Cartesian CS sequence (273 ± 21 s; P < 0.001). aCNR (7.7 ± 4.6 vs. 6.2 ± 2.8; P = 0.004) and aSNR (24.8 ± 9.7 vs. 18.8 ± 5.5; P < 0.001) were higher for the T2Cartesian CS compared to the T2PROPELLER CS sequence. The T2PROPELLER CS sequence significantly reduced (motion-)artifacts (P < 0.001) and increased image sharpness (P < 0.001), basal ganglia delineation (P<0.001), lesion conspicuity (raters 1 and 2, P < 0.001; rater 3, P = 0.004), and overall image quality (P < 0.001). Metal artifacts were prominent in both sequences, though slightly more pronounced in the T2PROPELLER CS sequence.
CONCLUSION: The T2PROPELLER CS sequence enables faster and motion-robust imaging of the brain in infants and children, reducing the rate of non-diagnostic scans and potentially allowing sedation or general anesthesia to be minimized in the future.
OBJECTIVE: Enabling faster and motion-robust MRI of the brain in infants and children using a novel, enhanced compressed sensing (CS) algorithm in combination with a turbo-spin-echo T2-weighted sequence utilizing the PROPELLER-technique (periodically rotated overlapping parallel lines with enhanced reconstruction; T2PROPELLER CS).
MATERIALS AND METHODS: This prospective study included 31 patients (8.0 ± 4.7 years, 15 males) undergoing a clinically indicated MRI examination of the brain on a 3-T scanner. The T2PROPELLER CS sequence was compared to a conventional, CS-accelerated Cartesian turbo-spin-echo T2-weighted sequence (T2Cartesian CS). Apparent contrast-to-noise ratio (aCNR) and signal-to-noise ratio (aSNR) were calculated. Three blinded radiologists independently rated both sequences twice qualitatively on a 5-point Likert-scale from 1-5 (non-diagnostic-excellent) for artifacts, image sharpness, basal ganglia delineation, lesion conspicuity, and overall image quality. Statistical analysis was performed using the Wilcoxon signed-rank test and paired sample t test. Intra- and interrater reliability of qualitative image assessment was evaluated by computing Krippendorff's α reliability estimates.
RESULTS: The average acquisition time of the T2PROPELLER CS (189 ± 27 s) was 31% shorter than that of the T2Cartesian CS sequence (273 ± 21 s; P < 0.001). aCNR (7.7 ± 4.6 vs. 6.2 ± 2.8; P = 0.004) and aSNR (24.8 ± 9.7 vs. 18.8 ± 5.5; P < 0.001) were higher for the T2Cartesian CS compared to the T2PROPELLER CS sequence. The T2PROPELLER CS sequence significantly reduced (motion-)artifacts (P < 0.001) and increased image sharpness (P < 0.001), basal ganglia delineation (P<0.001), lesion conspicuity (raters 1 and 2, P < 0.001; rater 3, P = 0.004), and overall image quality (P < 0.001). Metal artifacts were prominent in both sequences, though slightly more pronounced in the T2PROPELLER CS sequence.
CONCLUSION: The T2PROPELLER CS sequence enables faster and motion-robust imaging of the brain in infants and children, reducing the rate of non-diagnostic scans and potentially allowing sedation or general anesthesia to be minimized in the future.