PloS one · 2025
Evaluation of sugar meal administered anti-Leishmania compounds on the vectorial capacity of the vector, Lutzomyia longipalpis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Ferreira Tainá Neves, Latgé Samara Graciane Costa, Ramos Tadeu Diniz, Demidoff Felipe Cerqueira, Cunha-Júnior Edézio Ferreira, Costa Paulo Roberto Ribeiro, de Souza Marcus Vinícius Nora, Brandão Gomes Cláudia Regina, Dillon Viv Maureen, Netto Chaquip Daher, Torres Santos Eduardo Caio, Dillon Rod James, McDowell Mary Ann, de Matos Guedes Herbert Leonel, Genta Fernando Ariel
Аннотация
Multiple strategies involving the parasite-host-vector triad are necessary to control leishmaniasis. One option is to prevent or reduce transmission of the pathogen by the phlebotomine sand fly vectors. In this sense, it is essential to explore compounds that may influence the vectorial capacity of the insect and reduce its longevity. We investigated the effect of anti-Leishmania drugs administered via the sugar meal on longevity, blood feeding, oviposition, and parasite load on the third day of infection of the sand flies, to identify the most promising candidates for vector infection tests. We identified compounds that affected the longevity of sand flies (three pterocarpanquinones - LQB-475, LQB-181, and LQ-03; one hydroxyethylpiperazine, PMIC-4, and Pentamidine), reduced oviposition of females after blood feeding (LQB-181 and PMIC-4), but did not decrease infection rates or parasite loads. The results provide the effect of antiparasitic drugs from the perspective of the insect vector.