Dermatology (Basel, Switzerland) · 2005
Head and neck atopic dermatitis and malassezia-furfur-specific IgE antibodies.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Bayrou O, Pecquet C, Flahault A, Artigou C, Abuaf N, Leynadier F
Аннотация
BACKGROUND: Atopic dermatitis of the head and neck (HNAD) has been recognized as a separate entity. Malassezia furfur, a lipophilic yeast, is considered to be a pathogenic allergen in this form of atopic dermatitis.
OBJECTIVE: The purpose of this study was to determine the level of IgE anti-M.-furfur antibodies and their relation to the severity of the disease.
METHODS: IgE anti-M.-furfur antibodies were assayed in 106 patients with HNAD. Controls included 25 patients with non-HNAD, 20 with nonatopic dermatitis and 16 with seborrheic dermatitis (including 4 with AIDS).
RESULTS: There was a highly significant correlation between the level of anti-M.-furfur IgE and clinical severity. Furthermore, there was a significant but smaller correlation between total IgE and clinical severity. In patients with HNAD, total IgE was higher amongst men.
CONCLUSION: IgE anti-M.-furfur antibodies are a good and specific marker for HNAD. IgE M. furfur levels are strongly correlated with the severity of the disease.
OBJECTIVE: The purpose of this study was to determine the level of IgE anti-M.-furfur antibodies and their relation to the severity of the disease.
METHODS: IgE anti-M.-furfur antibodies were assayed in 106 patients with HNAD. Controls included 25 patients with non-HNAD, 20 with nonatopic dermatitis and 16 with seborrheic dermatitis (including 4 with AIDS).
RESULTS: There was a highly significant correlation between the level of anti-M.-furfur IgE and clinical severity. Furthermore, there was a significant but smaller correlation between total IgE and clinical severity. In patients with HNAD, total IgE was higher amongst men.
CONCLUSION: IgE anti-M.-furfur antibodies are a good and specific marker for HNAD. IgE M. furfur levels are strongly correlated with the severity of the disease.
Предметные рубрики MeSH
AdolescentAdultAge DistributionAgedAntibodies, FungalAntibody SpecificityCase-Control StudiesChildDermatitis, AtopicDermatitis, SeborrheicDermatomycosesFacial DermatosesFemaleHumansImmunoglobulin EIncidenceLinear ModelsMalasseziaMaleMiddle AgedNeckProbabilityPrognosisReference ValuesRisk AssessmentScalp DermatosesSeverity of Illness IndexSex Distribution