Psychological resilience moderates the relationship between childhood adversity, brain network connectivity, and wellness.

Childhood adversity impairs well-being, yet psychological resilience may buffer its impact. Using resting-state fMRI in 94 rural Chinese children (ages 10-14), we examined whether psychological resilience protects brain network connectivity from adversity and its relevance to psychological well-being. Psychological resilience significantly moderated the impact of abuse, but not neglect, on limbic connectivity. Low-resilience children exposed to abuse showed heightened limbic-somatomotor and limbic-ventral attention connectivity, which predicted greater somatization and depression at baseline and more severe levels of anxiety six months later. These associations were absent in high-resilience children. Our findings reveal that psychological resilience specifically shields against the neurotoxic effects of abuse by modulating networks involved in emotion regulation, salience, and sensorimotor processing. Targeted interventions should consider adversity dimensions and psychological resilience capacity to mitigate long-term mental health risks.