Biomacromolecules · 2025
In Situ Ionically Cross-Linkable Benzaldehyde-Modified Alginate and Its Bilayer Structure as a Tissue Sealant for Dural Closure.
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Yang I-Hsuan, Inagaki Natsuko F, Singh Chandel Arvind K, Matsumoto Mifuyu, Yamada Mai, Matsumiya Kazuki, Dai Yizhou, Iwabuchi Takaya, Onishi Kotaro, Fukushima Sonoko, Ohta Seiichi, Mizushima Akihiro, Isaji Mitsuko, Shimizu Satoshi, Takahata Masahiko, Iwasaki Norimasa, Ito Taichi
Аннотация
Effective tissue adhesives are vital for surgical applications. We synthesized p-aminobenzaldehyde-modified alginate (AL-ABA) with controlled degrees of substitution (DS, 3.8-13.7%) and cross-linked it ionically using CaCl2. AL-ABA solutions (3 w/v %) gelled rapidly (3-50 s), similar to unmodified alginate. Increasing DS reduced hydrogel stiffness but enhanced dura adhesiveness via Schiff's base formation with tissue amines, reaching 32 kPa at 9% DS. To optimize both adhesion and mechanical integrity, bilayer hydrogels were developed using an AL-ABA primer and AL cover layer, seamlessly bonded by ionic cross-linking. These AL-ABA/AL hydrogels showed strong dural adhesion and high burst pressure resistance (up to 406 mmHg). AL-ABA retained a low cytotoxicity and hemocompatibility. Ionically cross-linked AL-ABA and its bilayer configuration offer promising potential as biocompatible and efficient tissue sealants.