La Revue de medecine interne · 2001
[Sarcoidosis and comorbidity: retrospective study of 32 cases].
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Bonnet F, Dubuc J, Morlat P, Delbrel X, Doutre M S, de Witte S, Bernard N, Lacoste D, Longy-Boursier M, Beylot J
Аннотация
PURPOSE: A retrospective study was set up to investigate active pathologic processes associated with sarcoidosis diagnosed in 32 patients.
METHODS: Eighteen patients had two identified granulomatous localizations (56%) and 14 patients had three localizations or more (27%). Comorbidity was noticed in nine patients (28% of cases). Sarcoidosis was associated with an infectious disease five times (hepatitis C virus [HCV] infection three times, including one case after recombinant interferon alpha therapy, and HIV and HCV co-infection two times). The association of sarcoidosis with a chronic immunologic inflammatory disease was noticed four times (lupus erythematosus two times, myasthenia and primary biliary cirrhosis). Finally, in two cases sarcoidosis was associated with a neoplasia (non-Hodgkin's lymphoma in a co-infected HIV-HCV patient, ovarian cystadenocarcinoma in another patient). Sarcoidosis preceded or revealed the comorbidity four times.
METHODS: Eighteen patients had two identified granulomatous localizations (56%) and 14 patients had three localizations or more (27%). Comorbidity was noticed in nine patients (28% of cases). Sarcoidosis was associated with an infectious disease five times (hepatitis C virus [HCV] infection three times, including one case after recombinant interferon alpha therapy, and HIV and HCV co-infection two times). The association of sarcoidosis with a chronic immunologic inflammatory disease was noticed four times (lupus erythematosus two times, myasthenia and primary biliary cirrhosis). Finally, in two cases sarcoidosis was associated with a neoplasia (non-Hodgkin's lymphoma in a co-infected HIV-HCV patient, ovarian cystadenocarcinoma in another patient). Sarcoidosis preceded or revealed the comorbidity four times.
Предметные рубрики MeSH
AdultAgedComorbidityCystadenocarcinomaFemaleHIV InfectionsHepatitis CHumansImmune System DiseasesLiver Cirrhosis, BiliaryLupus Erythematosus, SystemicLymphoma, Non-HodgkinMaleMiddle AgedMyasthenia GravisNeoplasmsOvarian NeoplasmsResearch DesignRetrospective StudiesRisk FactorsSarcoidosisVirus Diseases