Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
Independent effect of body fat content on inflammatory biomarkers in children and adolescents: The GENOBOX study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Skapino Estela, Gonzalez-Gayan Laura, Seral-Cortes Miguel, Sabroso-Lasa Sergio, Llorente-Cereza Ma Teresa, Leis Rosaura, Aguilera Concepción M, Gil-Campos Mercedes, Moreno Luis A, Bueno-Lozano Gloria
Аннотация
BACKGROUND AND AIMS: To assess the relationship between body composition indicators and inflammatory biomarkers in children and adolescents of the GENOBOX study.
METHODS AND RESULTS: Anthropometry data from 264 subjects from the subsample of Zaragoza (Spain) included: weight, height, waist circumference, body mass index and triponderal index. Body composition was determined by Dual-energy X-ray Absorptiometry (DXA), obtaining visceral adipose tissue, fat mass index and lean mass index. Age and sex specific z-scores were computed. Simple linear regression models were performed with inflammatory biomarkers (hsCRP, IL8, TNF-α, adiponectin, leptin and resistin) as dependent variables, and each of the body composition indices as independent variables. Prepubertal boys had higher IL8 and resistin values and pubertal girls had higher HOMA-IR and leptin values. hsCPR and leptin were associated with fat mass, both in prepubertals and pubertals, independently of lean mass, and regardless of how body composition was measured. All body composition indices were inversely associated with adiponectin, except for fat mass index in pubertals, but none of them were statistically significant.
CONCLUSION: A positive association between hsCRP and leptin with all body fat composition parameters, measured by standard nutritional indicators and DXA, was observed in both sexual stages.
METHODS AND RESULTS: Anthropometry data from 264 subjects from the subsample of Zaragoza (Spain) included: weight, height, waist circumference, body mass index and triponderal index. Body composition was determined by Dual-energy X-ray Absorptiometry (DXA), obtaining visceral adipose tissue, fat mass index and lean mass index. Age and sex specific z-scores were computed. Simple linear regression models were performed with inflammatory biomarkers (hsCRP, IL8, TNF-α, adiponectin, leptin and resistin) as dependent variables, and each of the body composition indices as independent variables. Prepubertal boys had higher IL8 and resistin values and pubertal girls had higher HOMA-IR and leptin values. hsCPR and leptin were associated with fat mass, both in prepubertals and pubertals, independently of lean mass, and regardless of how body composition was measured. All body composition indices were inversely associated with adiponectin, except for fat mass index in pubertals, but none of them were statistically significant.
CONCLUSION: A positive association between hsCRP and leptin with all body fat composition parameters, measured by standard nutritional indicators and DXA, was observed in both sexual stages.