American journal of human genetics · 2013
Recessive mutations in SLC38A8 cause foveal hypoplasia and optic nerve misrouting without albinism.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАОбзорНазвание и аннотация: Перевод пока не подготовлен
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Poulter James A, Al-Araimi Musallam, Conte Ivan, van Genderen Maria M, Sheridan Eamonn, Carr Ian M, Parry David A, Shires Mike, Carrella Sabrina, Bradbury John, Khan Kamron, Lakeman Phillis, Sergouniotis Panagiotis I, Webster Andrew R, Moore Anthony T, Pal Bishwanath, Mohamed Moin D, Venkataramana Anandula, Ramprasad Vedam, Shetty Rohit, Saktivel Murugan, Kumaramanickavel Govindasamy, Tan Alex, Mackey David A, Hewitt Alex W, Banfi Sandro, Ali Manir, Inglehearn Chris F, Toomes Carmel
Аннотация
Foveal hypoplasia and optic nerve misrouting are developmental defects of the visual pathway and only co-occur in connection with albinism; to date, they have only been associated with defects in the melanin-biosynthesis pathway. Here, we report that these defects can occur independently of albinism in people with recessive mutations in the putative glutamine transporter gene SLC38A8. Nine different mutations were identified in seven Asian and European families. Using morpholino-mediated ablation of Slc38a8 in medaka fish, we confirmed that pigmentation is unaffected by loss of SLC38A8. Furthermore, by undertaking an association study with SNPs at the SLC38A8 locus, we showed that common variants within this gene modestly affect foveal thickness in the general population. This study reveals a melanin-independent component underpinning the development of the visual pathway that requires a functional role for SLC38A8.