The British journal of ophthalmology · 2025
Impact of mental health comorbidities on the effect of cataract surgery on dementia risk: a real-world retrospective cohort study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kao Shih-Kai, Yueh Ming-Pei, Yeh Huan-Jui, Cheng Hui-Chen
Аннотация
BACKGROUND: Cataract surgery has been shown to reduce the risk of developing dementia in the future; however, its impact on different dementia subtypes, including vascular dementia, remains unknown. Moreover, its dementia-protecting effect among cataract patients with common mental disorder (CMD) remains unclear.
METHODS: Patients aged 65 or older diagnosed with cataract between 2012 and 2021 were included and grouped based on whether they underwent cataract surgery within 1 year of diagnosis. Propensity-score matching was used to balance baseline characteristics, and Cox proportional hazards models were applied to assess dementia incidence within 5 years post-cataract between groups. Subgroup analyses were performed based on CMD status.
RESULTS: After propensity-score matching, 75 757 patients were included in both surgery and control groups. Cataract surgery significantly reduced dementia risk (HR=0.677, 95% CI =0.638 to 0.719, p<0.001), particularly for Alzheimer's disease (HR=0.643, 95% CI=0.576 to 0.716, p<0.001), with no significant effect on vascular dementia (HR=0.968, 95% CI=0.851 to 1.101, p=0.621). Subgroup analyses showed a significant reduction in dementia risk for patients without CMD (HR=0.666, 95% CI=0.624 to 0.710, p<0.001), but no protective effect in those with CMD, regardless of CMD status.
CONCLUSION: Cataract surgery is linked to a lower risk of dementia, especially Alzheimer's disease, in patients with cataract. However, this protective effect is diminished in those with CMD.
METHODS: Patients aged 65 or older diagnosed with cataract between 2012 and 2021 were included and grouped based on whether they underwent cataract surgery within 1 year of diagnosis. Propensity-score matching was used to balance baseline characteristics, and Cox proportional hazards models were applied to assess dementia incidence within 5 years post-cataract between groups. Subgroup analyses were performed based on CMD status.
RESULTS: After propensity-score matching, 75 757 patients were included in both surgery and control groups. Cataract surgery significantly reduced dementia risk (HR=0.677, 95% CI =0.638 to 0.719, p<0.001), particularly for Alzheimer's disease (HR=0.643, 95% CI=0.576 to 0.716, p<0.001), with no significant effect on vascular dementia (HR=0.968, 95% CI=0.851 to 1.101, p=0.621). Subgroup analyses showed a significant reduction in dementia risk for patients without CMD (HR=0.666, 95% CI=0.624 to 0.710, p<0.001), but no protective effect in those with CMD, regardless of CMD status.
CONCLUSION: Cataract surgery is linked to a lower risk of dementia, especially Alzheimer's disease, in patients with cataract. However, this protective effect is diminished in those with CMD.