Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2005
Longitudinal study on quality of life in 102 survivors of childhood craniopharyngioma.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Müller Hermann L, Bruhnken Gina, Emser Angela, Faldum Andreas, Etavard-Gorris Nicole, Gebhardt Ursel, Kolb Reinhard, Sörensen Niels
Аннотация
OBJECTS: We longitudinally analysed functional capacity and quality of life (QoL) in 102 patients with a childhood craniopharyngioma during follow-up.
METHODS: The Fertigkeitenskala Münster-Heidelberg (FMH) ability scale was used for QoL assessment. Multivariate analysis evaluated FMH scores at various time points, examining hypothalamus involvement (HI), body mass index (BMI), degree of resection, tumour progression, relapse and irradiation.
RESULTS AND CONCLUSION: Patients without HI (n=60) self-assessed higher QoL at baseline (p=0.001) and follow-up (p<0.001) than patients with HI (n=42). Only patients without HI evaluated at baseline >12 months after diagnosis showed longitudinal improvement in FMH scores (p=0.040). Rates of incomplete resection and irradiation were higher (p=0.070 and p=0.002 respectively) in patients with HI. In multivariate analysis, only HI, tumour relapse, progression, baseline FMH score, and time between diagnosis and baseline evaluation had independent impact on QoL. HI, tumour progression, and relapse had long-term QoL affects-most notably, severe obesity.
METHODS: The Fertigkeitenskala Münster-Heidelberg (FMH) ability scale was used for QoL assessment. Multivariate analysis evaluated FMH scores at various time points, examining hypothalamus involvement (HI), body mass index (BMI), degree of resection, tumour progression, relapse and irradiation.
RESULTS AND CONCLUSION: Patients without HI (n=60) self-assessed higher QoL at baseline (p=0.001) and follow-up (p<0.001) than patients with HI (n=42). Only patients without HI evaluated at baseline >12 months after diagnosis showed longitudinal improvement in FMH scores (p=0.040). Rates of incomplete resection and irradiation were higher (p=0.070 and p=0.002 respectively) in patients with HI. In multivariate analysis, only HI, tumour relapse, progression, baseline FMH score, and time between diagnosis and baseline evaluation had independent impact on QoL. HI, tumour progression, and relapse had long-term QoL affects-most notably, severe obesity.
Предметные рубрики MeSH
Activities of Daily LivingAdolescentAdultBody Mass IndexChildChild, PreschoolCombined Modality TherapyCraniopharyngiomaDisease ProgressionFemaleFollow-Up StudiesHumansHypophysectomyHypothalamusInfantLongitudinal StudiesMaleNeoplasm InvasivenessNeoplasm Recurrence, LocalObesityPituitary IrradiationPituitary NeoplasmsPostoperative ComplicationsPsychometricsQuality of LifeRadiotherapy, AdjuvantReproducibility of ResultsSelf-AssessmentSickness Impact ProfileSurvivors