Pollen-induced allergic rhinitis in 1360 Italian children: comorbidities and determinants of severity.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Dondi Arianna, Tripodi Salvatore, Panetta Valentina, Asero Riccardo, Businco Andrea Di Rienzo, Bianchi Annamaria, Carlucci Antonio, Ricci Giampaolo, Bellini Federica, Maiello Nunzia, del Giudice Michele Miraglia, Frediani Tullio, Sodano Simona, Dello Iacono Iride, Macrì Francesco, Massaccesi Valerio, Caffarelli Carlo, Rinaldi Laura, Patria Maria Francesca, Varin Elena, Peroni Diego, Chinellato Iolanda, Chini Loredana, Moschese Viviana, Lucarelli Sandra, Bernardini Roberto, Pingitore Giuseppe, Pelosi Umberto, Tosca Mariangela, Paravati Francesco, La Grutta Stefania, Meglio Paolo, Calvani Mauro, Plebani Mario, Matricardi Paolo Maria, Italian Pediatric Allergy Network (I-PAN)
Аннотация
OBJECTIVES: To investigate the severity of pollen-induced AR and its determinants in Italian children referred to allergy specialists and who had never received specific immunotherapy (SIT).
METHODS: Children (age 4-18 yr) affected by pollen-induced AR who had never undergone SIT were recruited between May 2009 and June 2011 in 16 pediatric outpatient clinics in 14 Italian cities. Recruited children's parents answered standardized questionnaires on atopic diseases (International Study of Allergy and Asthma in Childhood, Allergic Rhinitis and its Impact on Asthma, Global Initiative for Asthma). The children underwent skin-prick test (SPT) with several airborne allergens and six food allergens. Information on socio-demographic factors, parental history of allergic diseases, education, perinatal events, breastfeeding, nutrition and environmental exposure in early life was collected through an informatics platform shared by the whole network of clinical centers (AllergyCARD™).
RESULTS: Among the 1360 recruited patients (68% males, age 10.5 ± 3.4 yr), 695 (51%) had moderate-to-severe AR, 533 (39%) asthma, and 325 (23.9%) oral allergy syndrome (OAS). Reported onset of pollen-induced AR was on average at 5.3 ± 2.8 yr, and its mean duration from onset was 5.2 ± 3.3 yr. Only 6.2% of the patients were pollen-monosensitized, and 84.9% were sensitized to ≥3 pollens. A longer AR duration was significantly associated with moderate-to-severe AR symptoms (p 0.004), asthma (p 0.030), and OAS comorbidities (p < 0.001).
CONCLUSIONS: This nationwide study may raise awareness of the severity of pollen-induced AR among Italian children who have never received pollen SIT. The strong association between pollen-induced AR duration and several markers of disease severity needs replication in longitudinal studies, while suggesting that countrywide initiatives for earlier diagnosis and intervention should be planned.