Indian journal of pharmacology · 2013
Retrospective analysis of Steven Johnson syndrome and toxic epidermal necrolysis over a period of 5 years from northern Karnataka, India.
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Naveen Kikkeri Narayanasetty, Pai Varadraj V, Rai Vijetha, Athanikar Sharatchandra B
Аннотация
OBJECTIVE: Cutaneous drug reactions are the most common type of adverse drug reactions. Adverse cutaneous drug reactions form 2-3% of the hospitalized patients. 2% of these are potentially serious. This study aims to detect the drugs commonly implicated in Steven Johnson Syndrome-Toxic Epidermal Necrosis (SJS-TEN).
MATERIALS AND METHODS: A retrospective analysis was done in all patients admitted in the last five years in SDM hospital with the diagnosis of SJS-TEN.
RESULTS: A total of 22 patients with SJS-TEN were studied. In 11 patients anti-epileptics was the causal drug and in 7, anti-microbials was the causal drug. Recovery was much faster in case of anti epileptics induced SJS-TEN as compared to that induced by ofloxacin.
CONCLUSION: SJS-TEN induced by ofloxacin has a higher morbidity and mortality compared to anti convulsants.
MATERIALS AND METHODS: A retrospective analysis was done in all patients admitted in the last five years in SDM hospital with the diagnosis of SJS-TEN.
RESULTS: A total of 22 patients with SJS-TEN were studied. In 11 patients anti-epileptics was the causal drug and in 7, anti-microbials was the causal drug. Recovery was much faster in case of anti epileptics induced SJS-TEN as compared to that induced by ofloxacin.
CONCLUSION: SJS-TEN induced by ofloxacin has a higher morbidity and mortality compared to anti convulsants.