Respiratory medicine · 2025
Cystic Fibrosis (CF) and Modulators Based Therapy (CFTR) in oral and salivary perspectives: A single center cross-sectional study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Cofta Sz, Paszynska E, Roszak M, Kopycka-Kedzierawski D T, Otulakowska-Skrzynska J, Hernik A, Winiarska H, Springer D, Rataj M, Wysocka E, Dworacka M, Suchodolski M, Dmitrzak-Weglarz M
Аннотация
OBJECTIVES: Recently introduced modulators-based therapy for cystic fibrosis (CF), provides new opportunity for better health outcomes and longer life. Single center cross-sectional aim of this study was to determine oral health status of adult CF patients, treated with CFTR modulators (CFTR-T), with no modulators (CFTR-0) in comparison to matched healthy individuals (Ctrl).
MATERIALS AND METHODS: Among 52 CF adult outpatients (male n = 24/female n = 28, 18-49y.) 34 were treated with triple-combination CFTR modulators (elexacaftor/tezacaftor/ivacaftor). Oral assessments included caries prevalence (Decayed, Missing, Filled teeth DMFT), dental hygiene (Plaque Control Record PCR), bleeding on probing (BOP), salivary mucins 5B/7, lysozyme, alpha-amylase (ELISA/PCR tests).
RESULTS: There was statistically significant difference between CF and Ctrl groups in decayed teeth (respectively median (min-max) 1 (0-12) vs. 0 (0-3) p < 0.001), PCR% (22.5 (0-100) vs. 10 (0-60) p < 0.001), BOP% (0 (0-39) vs. 0 (0-30) p < 0.006). Significantly higher concentrations of mucins 5b,7 and lysozyme (0.9 (0.3-20.9), 2.8 (0.9-12.8), 11.1 (5-31), all p < 0.001). In CFTR-T subgroup significantly higher dental plaque (31.5 (1-100) vs. 10 (0-60), p < 0.001) and lysozyme (8.8 (5-15.5), p < 0.001). Noteworthy, CFTR-T recipients gained weight (p = 0.002).
CONCLUSIONS: Adult patients with CF showed higher susceptibility to dental caries, poorer oral hygiene and sustain proinflammatory status. However novel modulator therapy reduced the level of salivary mucins and enzymes.
MATERIALS AND METHODS: Among 52 CF adult outpatients (male n = 24/female n = 28, 18-49y.) 34 were treated with triple-combination CFTR modulators (elexacaftor/tezacaftor/ivacaftor). Oral assessments included caries prevalence (Decayed, Missing, Filled teeth DMFT), dental hygiene (Plaque Control Record PCR), bleeding on probing (BOP), salivary mucins 5B/7, lysozyme, alpha-amylase (ELISA/PCR tests).
RESULTS: There was statistically significant difference between CF and Ctrl groups in decayed teeth (respectively median (min-max) 1 (0-12) vs. 0 (0-3) p < 0.001), PCR% (22.5 (0-100) vs. 10 (0-60) p < 0.001), BOP% (0 (0-39) vs. 0 (0-30) p < 0.006). Significantly higher concentrations of mucins 5b,7 and lysozyme (0.9 (0.3-20.9), 2.8 (0.9-12.8), 11.1 (5-31), all p < 0.001). In CFTR-T subgroup significantly higher dental plaque (31.5 (1-100) vs. 10 (0-60), p < 0.001) and lysozyme (8.8 (5-15.5), p < 0.001). Noteworthy, CFTR-T recipients gained weight (p = 0.002).
CONCLUSIONS: Adult patients with CF showed higher susceptibility to dental caries, poorer oral hygiene and sustain proinflammatory status. However novel modulator therapy reduced the level of salivary mucins and enzymes.