EBioMedicine · 2015
Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Jabbari Ali, Dai Zhenpeng, Xing Luzhou, Cerise Jane E, Ramot Yuval, Berkun Yackov, Sanchez Gina A Montealegre, Goldbach-Mansky Raphaela, Christiano Angela M, Clynes Raphael, Zlotogorski Abraham
Аннотация
BACKGROUND: Alopecia areata (AA) is an autoimmune disease resulting in hair loss with devastating psychosocial consequences. Despite its high prevalence, there are no FDA-approved treatments for AA. Prior studies have identified a prominent interferon signature in AA, which signals through JAK molecules.
METHODS: A patient with AA was enrolled in a clinical trial to examine the efficacy of baricitinib, a JAK1/2 inhibitor, to treat concomitant CANDLE syndrome. In vivo, preclinical studies were conducted using the C3H/HeJ AA mouse model to assess the mechanism of clinical improvement by baricitinib.
FINDINGS: The patient exhibited a striking improvement of his AA on baricitinib over several months. In vivo studies using the C3H/HeJ mouse model demonstrated a strong correlation between resolution of the interferon signature and clinical improvement during baricitinib treatment.
INTERPRETATION: Baricitinib may be an effective treatment for AA and warrants further investigation in clinical trials.
METHODS: A patient with AA was enrolled in a clinical trial to examine the efficacy of baricitinib, a JAK1/2 inhibitor, to treat concomitant CANDLE syndrome. In vivo, preclinical studies were conducted using the C3H/HeJ AA mouse model to assess the mechanism of clinical improvement by baricitinib.
FINDINGS: The patient exhibited a striking improvement of his AA on baricitinib over several months. In vivo studies using the C3H/HeJ mouse model demonstrated a strong correlation between resolution of the interferon signature and clinical improvement during baricitinib treatment.
INTERPRETATION: Baricitinib may be an effective treatment for AA and warrants further investigation in clinical trials.