Allergologia et immunopathologia · 2005
[Exposition and sensitization to Tyrophagus putrescentiae in a allergic population to Dermatophagoides pteronyssinus in Huelva, Spain].
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Arias J, Lombardero M, Arteaga C, Barber D
Аннотация
BACKGROUND: In this work we analyzed the allergological importance of Tyrophagus putrescentiae (Tp) in Huelva (SE Spain). We studied the level of exposition and the grade of sensitization to Tp in a group of patients sensitized to Dermatophagoides pteronyssinus (Dpt). The allergenic cross-reactivity between Dpt and Tp was determined by RAST inhibition.
METHODS AND RESULTS: We analyzed house dust samples from the dwellings of allergic patients with documented Dpt sensitization. Skin test (ST), conjunctival provocation (CP) and/or specific IgE (RAST) to Tp were performed when Tp was identificated in the house dust sample of the patient. Among the 136 dust samples studied, Dpt was the most frequently identified mite species (94.8%) and Tp was found in third position (41.1%) after Glycyphagus domesticus (54.4%). Among the 45 patients studied, 23 (51.1%) presented, at least, two positive tests, 18 (40%) were not sensitized to Tp and 4 (8.8%) showed contradictory results. 26 patients (57.7%) inhabited in urban areas and 19 (42.2%) in rural regions. We determined specific IgE (RAST) to Tp in 25 patients, and the results were positive in 12, with only 7 with values greater than 2 kU/L. No significant correlation were found between IgE-antibody levels to Dpt and Tp. The RAST inhibition studies confirmed the low cross-reactivity between these mites and only in one patient Dpt partially inhibited the IgE-binding to Dpt extract.
CONCLUSIONS: Tp was the second more frequent storage mite in the house dust samples from patients allergic to Dpt in Huelva. However, only half of the exposed patients were sensitized to Tp and the majority inhabited in urban areas. No significant correlation were found between IgE-antibody levels to Dpt and Tp. The RAST inhibition studies confirmed the low cross-reactivity between these mites.
METHODS AND RESULTS: We analyzed house dust samples from the dwellings of allergic patients with documented Dpt sensitization. Skin test (ST), conjunctival provocation (CP) and/or specific IgE (RAST) to Tp were performed when Tp was identificated in the house dust sample of the patient. Among the 136 dust samples studied, Dpt was the most frequently identified mite species (94.8%) and Tp was found in third position (41.1%) after Glycyphagus domesticus (54.4%). Among the 45 patients studied, 23 (51.1%) presented, at least, two positive tests, 18 (40%) were not sensitized to Tp and 4 (8.8%) showed contradictory results. 26 patients (57.7%) inhabited in urban areas and 19 (42.2%) in rural regions. We determined specific IgE (RAST) to Tp in 25 patients, and the results were positive in 12, with only 7 with values greater than 2 kU/L. No significant correlation were found between IgE-antibody levels to Dpt and Tp. The RAST inhibition studies confirmed the low cross-reactivity between these mites and only in one patient Dpt partially inhibited the IgE-binding to Dpt extract.
CONCLUSIONS: Tp was the second more frequent storage mite in the house dust samples from patients allergic to Dpt in Huelva. However, only half of the exposed patients were sensitized to Tp and the majority inhabited in urban areas. No significant correlation were found between IgE-antibody levels to Dpt and Tp. The RAST inhibition studies confirmed the low cross-reactivity between these mites.