Journal of dentistry · 2025
Oraltypes of the human oral bacteriome and mycobiome.
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Wang Xu, Zhang Xinming, Wu Shuangshuang, Yan Zhimin
Аннотация
OBJECTIVES: The inter‑individual variations in oral microbial composition remain largely unknown. This study aims to identify the bacterial and fungal compositional patterns of human oral microbiome.
METHODS: A total of 389 bacterial samples from 5 cohorts and 118 fungal samples from 3 cohorts were collected. Partitioning around medoid (PAM) clustering method was used to cluster the samples of 16S and ITS amplification, respectively. Considering that the clusters identified in gut microbiome were previously named as "enterotypes", the identified clusters in oral microbiome were called "oraltypes".
RESULTS: In the oral bacteriome, Prevotella, Streptococcus and Neisseria were the most abundant genera. Meanwhile, two bacterial "oraltypes" dominated by Neisseria and Veillonella were identified. In the oral mycobiome, Candida and Malassezia were the most abundant genera, which were also the dominant genera of the two identified fungal "oraltypes". Further analysis showed that bacterial "oraltypes" were associated with the human age.
CONCLUSIONS: There are two bacterial and two fungal compositional patterns in human oral microbiome.
CLINICAL SIGNIFICANCE: This study identified the "oraltypes", which can be used to depict the homogeneity and heterogeneity of oral microbiota among populations, as well as to analyze the susceptibility to certain diseases in different individuals.
METHODS: A total of 389 bacterial samples from 5 cohorts and 118 fungal samples from 3 cohorts were collected. Partitioning around medoid (PAM) clustering method was used to cluster the samples of 16S and ITS amplification, respectively. Considering that the clusters identified in gut microbiome were previously named as "enterotypes", the identified clusters in oral microbiome were called "oraltypes".
RESULTS: In the oral bacteriome, Prevotella, Streptococcus and Neisseria were the most abundant genera. Meanwhile, two bacterial "oraltypes" dominated by Neisseria and Veillonella were identified. In the oral mycobiome, Candida and Malassezia were the most abundant genera, which were also the dominant genera of the two identified fungal "oraltypes". Further analysis showed that bacterial "oraltypes" were associated with the human age.
CONCLUSIONS: There are two bacterial and two fungal compositional patterns in human oral microbiome.
CLINICAL SIGNIFICANCE: This study identified the "oraltypes", which can be used to depict the homogeneity and heterogeneity of oral microbiota among populations, as well as to analyze the susceptibility to certain diseases in different individuals.