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Войти в исследования Neuroreport · 2026
Neuroprotective effects of an oxindole-piperine hybrid in a rat model of ischemic stroke.
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Ahmed Al-Shaimaa F, Ali Taha F S, Fareed Momen R, Anter Aliaa F, Abdel Hameed Sarah S, El-Daly Mahmoud E, Shehata Alaa H
Аннотация
OBJECTIVE: Numerous studies suggest that oxindole-based derivatives exert neuroprotective activity on neurons. However, these studies used in-vitro evaluation methods and were not evaluated in vivo . Thus, this study aimed to test and assess the neuroprotective effect of a synthetic compound (OP1) by Knoevenagel condensation of cinnamaldehyde and oxindole.
METHODS: In this study, we used a model of global cerebral ischemia to evaluate the neuroprotective effects of OP1. This was achieved by measuring the behavioral outcomes and infarct volume.
RESULTS: The results showed that OP1 resulted in a significant improvement in open field, beam walk, and tape removal tests compared with ischemic rats. Also, OP1 reduced the infarct size after induction of ischemia.
CONCLUSION: OP1 shows a promising neuroprotective effect against cerebral ischemia.
METHODS: In this study, we used a model of global cerebral ischemia to evaluate the neuroprotective effects of OP1. This was achieved by measuring the behavioral outcomes and infarct volume.
RESULTS: The results showed that OP1 resulted in a significant improvement in open field, beam walk, and tape removal tests compared with ischemic rats. Also, OP1 reduced the infarct size after induction of ischemia.
CONCLUSION: OP1 shows a promising neuroprotective effect against cerebral ischemia.