Control of volitional and reflexive saccades in Tourette's syndrome.

We hypothesized that Tourette's syndrome (TS) patients would display abnormal control of saccades because of overlap between brain areas suspected in TS pathophysiology and those involved saccade control. Subjects were required to look toward (pro-saccade) or away from (anti-saccade) a visual target. Saccadic reaction times were elevated among TS subjects in all tasks. The occurrence of reflexive pro-saccades in the immediate anti-saccade task was normal, suggesting that the ability to inhibit reflexive saccades was not impaired in TS. However, timing errors (eye movements made prior to GO signal in delayed saccade tasks) were increased in TS indicating that ability to inhibit or delay planned motor programs is significantly impaired in TS.