Emerging infectious diseases · 2006
Bat-transmitted human rabies outbreaks, Brazilian Amazon.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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da Rosa Elizabeth S T, Kotait Ivanete, Barbosa Taciana F S, Carrieri Maria L, Brandão Paulo E, Pinheiro Amiraldo S, Begot Alberto L, Wada Marcelo Y, de Oliveira Rosely C, Grisard Edmundo C, Ferreira Márcia, Lima Reynaldo J da Silva, Montebello Lúcia, Medeiros Daniele B A, Sousa Rita C M, Bensabath Gilberta, Carmo Eduardo H, Vasconcelos Pedro F C
Аннотация
We describe 2 bat-transmitted outbreaks in remote, rural areas of Portel and Viseu Municipalities, Pará State, northern Brazil. Central nervous system specimens were taken after patients' deaths and underwent immunofluorescent assay and histopathologic examination for rabies antigens; also, specimens were injected intracerebrally into suckling mice in an attempt to isolate the virus. Strains obtained were antigenically and genetically characterized. Twenty-one persons died due to paralytic rabies in the 2 municipalities. Ten rabies virus strains were isolated from human specimens; 2 other cases were diagnosed by histopathologic examination. Isolates were antigenically characterized as Desmodus rotundus variant 3 (AgV3). DNA sequencing of 6 strains showed that they were genetically close to D. rotundus-related strains isolated in Brazil. The genetic results were similar to those obtained by using monoclonal antibodies and support the conclusion that the isolates studied belong to the same rabies cycle, the virus variants found in the vampire bat D. rotundus.